Physiological Response to Prone Position in COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS)

Completed

• Conditions: ARDS; Sars-CoV-2 Infection

• Registration Number: NCT05092737
• Lead Sponsor: University of Lausanne Hospitals

Brief Summary

Retrospective study in COVID-19 ARDS patients hospitalised in the ICU. Investigators aim to explore the effects of prone positioning on oxygenation, dead space ventilation and mortality.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-08-01
• Status Verified: 2021-10
• Study First Submitted: 2021-10-21
• Study First Submitted QC: 2021-10-21
• Study First Posted: 2021-10-25
• Primary Completion: 2022-04-30
• Study Completion: 2022-04-30
• Last Update Submitted: 2022-06-02
• Last Update Posted: 2022-06-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 31

Inclusion Criteria

• COVID-19 associated moderate to severe ARDS
• Invasive mechanical ventilation
• Prone positioning
• admitted to ICU

Exclusion Criteria

• already sustained prone positioning in referring hospital
• pronation during ECMO only
• denied consent for data analysis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
PaO2/FiO2	Within 2 hours before pronation and 2 hours before supination	Arterial partial pressure of oxygen / Fraction of inspired oxygen

Secondary Outcome Measures

Name	Time	Method
Ventilatory Ratio	Within 2 hours before pronation and 2 hours before supination
Alveolo-arterial oxygen gradient change	Within 2 hours before pronation and 2 hours before supination
Mortality or Extracorporeal membrane oxygenation (ECMO) support	Once between ICU admission and extubation

Trial Locations

Locations (1)

Lausanne University Hospitals; 🇨🇭 Lausanne, Vaud, Switzerland