Effects of Analgesia Nociception Index (ANI)-Guided Analgesia on Postoperative Bowel Function Recovery in Laparoscopic Colorectal Surgery: A Prospective Randomized-controlled Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Postoperative Bowel Function Recovery
- Sponsor
- Gangnam Severance Hospital
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Time to first gas passing from surgery
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Investigators will examaine the effects of Analgesia Nociception Index (ANI)-guided analgesia on postoperative bowel function recovery in laparoscopic colorectal surgery. This is a prospective randomized-controlled study.
Investigators will randomly divide the patients into two groups. In ANI group, remifentanil infusion rate during anesthesia will be adjusted according to ANI monitoring. In Control group, remifentanil infusion rate during anesthesia will be adjusted according to the conventional method of blood pressure and heart rate monitroing. And Investigators will evalualte the bowel function recovery in both groups after surgery, and compare between the two groups.
Investigators
Young Song
Associate Professor
Gangnam Severance Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients over 19 years who undergo laparoscopic colorectal surgery for colorectal cancer at Gangnam Severance Hospital, Seoul, South Korea.
Exclusion Criteria
- •Emergency surgery
- •Patients undergoing colostomy
- •Patients with history of open abdominal surgery
- •Patients with arrhythmia
- •Patients with pacemaker insertion
- •Patients with history of heart transplantation
- •Patients taking medications that may affect ANI (antimuscarinics, alpha-agonists, beta blockers)
- •Patients with chronic opioid medication.
- •Cognitive impairment
- •Unable to read consent form (eg illiterate, foreigner, etc.)
Outcomes
Primary Outcomes
Time to first gas passing from surgery
Time Frame: Up to postoperative 2weeks
Time (hours) to first gas passing from surgery
Secondary Outcomes
- Postoperative opioid consumption(postoperative 6hours, 12hours, 24hours, 36hours, 48hours, 3days, 4days, 5days.(Minimum value: 0, Maximum value: 10, higher score means worse.))
- Time to starting fluid intake from surgery(up to 2weeks)
- Time to first rescue analgesics from surgery(up to 2weeks)
- Time to starting soft diet from surgery(up to 2 weeks)
- Nausea score(postoperative 6hours, 12hours, 24hours, 36hours, 48hours, 3days, 4days, 5days)
- Number of vomiting, antiemetic administration(up to 2weeks)
- Time to starting ambulation from surgery.(up to 2 weeks)
- QoR-15(postoperative 1days, 4days)
- Plasma concentration of Cortisol, Norepinephrine, Epinephrine, IL-6(immediately after surgery)
- Intraoperative opioid consumption(during anesthesia)
- Pain score(postoperative 6hours, 12hours, 24hours, 36hours, 48hours, 3days, 4days, 5days.(Minimum value: 0, Maximum value: 10, higher score means worse.))
- Hemodynamics during anesthesia(during anesthesia)