Effects of Cardiac Resynchronization Therapy on the Microcirculation (CaRe-Mi)

• Conditions: alterations of microcirculation; chronic heart failure; weak heart; 10019280

• Registration Number: NL-OMON32204
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 51

Inclusion Criteria

* Older than 18 years
* Chronic heart failure
* CRT device implanted
* Informed consent is given

Exclusion Criteria

* Younger than 18 years
* Pacing dependency (no intrinsic rhythm)
* Pre-existing renal failure requiring dialysis
* Known haemoglobin diseases, such as sickle cell anemia or thallasemia
* Known allergy to acetylcholine or its additives
* Missing informed consent
* Inability to walk

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the CRT- and acetylcholine-related effects on the<br /><br>microcirculation as expressed as the change in mean functional capillary<br /><br>density during different pacing settings and pharmacologic vasodilatation.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary parameters are additional microvascular parameters: red blood cell<br /><br>velocity and microvascular flow index (MFI). Furthermore, the correlation of<br /><br>microcirculatory and systemic hemodynamic parameters will be investigated.</p><br>