hypoxia-inducible factor-1 alpha is a key regulator of angiogenesis and inflammation in rheumatoid arthritis: a case-control study
Not Applicable
Recruiting
- Conditions
- Rheumatoid Arthritis
- Registration Number
- ITMCTR1900002659
- Lead Sponsor
- Shanghai Traditional Medicine University Affiliated Guanghua Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- Not specified
Inclusion Criteria
Criteria for RA:
(1) patients with definite diagnosis of rheumatoid arthritis;
(2) patients have no serious primary diseases, chronic wasting diseases and mental disorders such as cardiac, cerebrovascular, liver, kidney and hematopoietic system;
(3) patients with knee joint pain accompanied by destruction need knee joint replacement;
(4) patients have better compliance and can complete the whole course of treatment.
Exclusion Criteria
(1) the patients refused to undergo knee replacement;
(2) the patients have surgical contraindications;
(3) those with poor compliance or who are participating in other drug trials;
(4) patients who have not been treated with this test protocol as required.
Study & Design
- Study Type
- Basic Science
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method VEGFA;INOS;HIF-1 alpha;
- Secondary Outcome Measures
Name Time Method