Research of increased gas by lactulose load test in irritable bowel syndrome
Phase 1
- Conditions
- irritable bowel syndrome, small intestinal bacterial overgrowth
- Registration Number
- JPRN-UMIN000018422
- Lead Sponsor
- Office Uno column
- Brief Summary
At a dose of 10 g lactulose and an observation time of two hours, patients displayed no symptoms, and the gas volume was only slightly increased. However, when the dose of lactulose was increased (13 g/50 kg), and the observation time for the lactulose challenge was extended to 240-300 minutes, the results clearly demonstrated an increase in the gas produced in IBS patients. Open Journal of Gastroenterology, 2015, 5, 155-163
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
Not provided
Exclusion Criteria
Person who suffering from organic diseases. (When disease is not healed).
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Imaging is first performed in early morning after fasting. After ingestion of lactulose, 1-4 plain abdominal radiographs are taken for investigation of increased gas during the indicated timeframe. Regions of interest of the gas areas are highlighted on the images obtained. Gas images were divided into three areas, the stomach, small intestine, and large intestine, and each total area is calculated.
- Secondary Outcome Measures
Name Time Method It is investigated the relationship between the symptoms and the gas of the amount which appears after lactulose load. By that relationship, it will determine whether it is possible to diagnosis of IBS and SIBO only a symptom of post-lactulose load.