Study of Baricitinib (LY3009104) in Patients With Moderate to Severe Atopic Dermatitis
- Registration Number
- NCT03334422
- Lead Sponsor
- Eli Lilly and Company
- Brief Summary
The purpose of this study is to evaluate the efficacy and safety of baricitinib as monotherapy in participants with moderate to severe atopic dermatitis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 615
- Have been diagnosed with moderate to severe Atopic Dermatitis for at least 12 months.
- Have had inadequate response or intolerance to existing topical (applied to the skin) medications within 6 months preceding screening.
- Are willing to discontinue certain treatments for eczema (such as systemic and topical treatments during a washout period).
- Agree to use emollients daily.
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Are currently experiencing or have a history of other concomitant skin conditions (e.g., psoriasis or lupus erythematosus), or a history of erythrodermic, refractory, or unstable skin disease that requires frequent hospitalizations and/or intravenous treatment for skin infections.
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A history of eczema herpeticum within 12 months, and/or a history of 2 or more episode of eczema herpeticum in the past.
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Participants who are currently experiencing a skin infection that requires treatment, or is currently being treated, with topical or systemic antibiotics.
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Have any serious illness that is anticipated to require the use of systemic corticosteroids or otherwise interfere with study participation or require active frequent monitoring (e.g., unstable chronic asthma).
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Have been treated with the following therapies:
- Monoclonal antibody for less than 5 half-lives prior to randomization.
- Received prior treatment with any oral Janus kinase (JAK) inhibitor.
- Received any parenteral corticosteroids administered by intramuscular or intravenous (IV) injection within 2 weeks prior to study entry or within 6 weeks prior to planned randomization or are anticipated to require parenteral injection of corticosteroids during the study.
- Have had an intra-articular corticosteroid injection within 2 weeks prior to study entry or within 6 weeks prior to planned randomization.
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Have high blood pressure characterized by a repeated systolic blood pressure >160 millimeters of mercury (mm Hg) or diastolic blood pressure >100 mm Hg.
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Have had major surgery within the past eight weeks or are planning major surgery during the study.
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Have experienced any of the following within 12 weeks of screening: venous thromboembolic event (VTE), myocardial infarction (MI), unstable ischemic heart disease, stroke, or New York Heart Association Stage III/IV heart failure.
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Have a history of recurrent (≥ 2) VTE or are considered at high risk of VTE as deemed by the investigator.
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Have a history or presence of cardiovascular, respiratory, hepatic, chronic liver disease gastrointestinal, endocrine, hematological, neurological, lymphoproliferative disease or neuropsychiatric disorders or any other serious and/or unstable illness.
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Have a current or recent clinically serious viral, bacterial, fungal, or parasitic infection including herpes zoster, tuberculosis.
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Have specific laboratory abnormalities.
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Have received certain treatments that are contraindicated.
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Pregnant or breastfeeding.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1mg Baricitinib Placebo 1mg Baricitinib administered orally once daily. Placebo 2 mg and 4 mg administered orally every day to match. 4 Milligram (mg) Baricitinib Placebo 4mg Baricitinib administered orally once daily. Placebo 1 mg and 2 mg administered orally every day to match Placebo Placebo Placebo administered orally once daily. 2mg Baricitinib Placebo 2mg Baricitinib administered orally once daily. Placebo 1 mg and 4 mg administered orally every day to match. 4 Milligram (mg) Baricitinib Baricitinib 4mg Baricitinib administered orally once daily. Placebo 1 mg and 2 mg administered orally every day to match 2mg Baricitinib Baricitinib 2mg Baricitinib administered orally once daily. Placebo 1 mg and 4 mg administered orally every day to match. 1mg Baricitinib Baricitinib 1mg Baricitinib administered orally once daily. Placebo 2 mg and 4 mg administered orally every day to match.
- Primary Outcome Measures
Name Time Method Percentage of Participants Achieving Investigator's Global Assessment (IGA) of 0 or 1 With a ≥ 2 Point Improvement (Placebo, 2mg and 4mg Baricitinib) 16 Weeks The IGA measures the investigator's global assessment of the participants overall severity of their atopic dermatitis (AD), based on a static, numeric 5-point scale from 0 (clear skin) to 4 (severe disease). The score is based on an overall assessment of the degree of erythema, papulation/induration, oozing/crusting, and lichenification.
- Secondary Outcome Measures
Name Time Method Percentage of Participants Achieving EASI90 16 Weeks The EASI assesses objective physician estimates of 2 dimensions of atopic dermatitis - disease extent and clinical signs affected: 0 = 0%; 1 = 1-9%; 2 = 10-29%; 3 = 30-49%; 4 = 50-69%; 5 = 70-89%; 6 = 90-100%) and the severity of 4 clinical signs (1) erythema, (2)edema/papulation, (3) excoriation, and (4) lichenification each on a scale of 0 to 3 (0 = none, absent; 1 = mild; 2 = moderate; 3 = severe) at 4 body sites (head/neck, trunk, upper limbs, and lower limbs). Half scores are allowed between severities 1, 2 and 3. The final EASI score is obtained by weight-averaging these 4 scores and will range from 0 to 72 (severe). The EASI90 is defined as a ≥ 90% improvement from baseline in the EASI score.
Percentage of Participants Achieving SCORing Atopic Dermatitis 75 (SCORAD75) 16 Weeks The SCORAD index uses the rule of nines to assess disease extent and evaluates 6 clinical characteristics to determine disease severity: (1) erythema, (2) edema/papulation, (3) oozing/crusts, (4) excoriation, (5) lichenification, and (6) dryness on a scale of 0 to 3 (0=absence, 1=mild, 2=moderate, 3=severe). The SCORAD index also assesses subjective symptoms of pruritus and sleep loss with VAS where 0 is no itching or no trouble sleeping and 10 is unbearable Itching or lot of trouble sleeping. These 3 aspects: extent of disease (A: 0-1-2), disease severity (B: 0-18), \& subjective symptoms (C: 0-20) combine using A/5 + 7\*B/2+ C to give a maximum possible score of 103, where 0 = no disease and 103 = severe disease. The SCORAD75 responder is defined as a participant who achieves a ≥ 75% improvement from baseline in the SCORAD score.
Percentage of Participants Achieving a 4-Point Improvement in Itch Numeric Rating Scale (NRS) 16 Weeks The Itch Numeric Rating Scale (NRS) is a participant-administered, 11-point horizontal scale anchored at 0 and 10, with 0 representing "no itch" and 10 representing "worst itch imaginable." Overall severity of a participants itching is indicated by selecting the number, using a daily diary, that best describes the worst level of itching in the past 24 hours.
Percentage of Participants Achieving IGA of 0 or 1 With a ≥ 2 Point Improvement (Placebo, 1mg Baricitinib) 16 Weeks The IGA measures the investigator's global assessment of the participants overall severity of their AD, based on a static, numeric 5-point scale from 0 (clear skin) to 4 (severe disease). The score is based on an overall assessment of the degree of erythema, papulation/induration, oozing/crusting, and lichenification.
Change From Baseline in the Score of Item 2 of the Atopic Dermatitis Sleep Scale (ADSS) Baseline, 16 Weeks Atopic Dermatitis Sleep Scale (ADSS) is a 3-item, participant-administered questionnaire developed to assess the impact of itch on sleep including difficulty falling asleep, frequency of waking, and difficulty getting back to sleep last night. Item 2, frequency of waking last night is reported by selecting the number of times they woke up each night, ranging from 0 to 29 times, where the higher a number indicates a worse outcome. The ADSS is designed to be completed daily, using a daily diary, with respondents thinking about sleep "last night." Each item is scored individually.
LS Means were calculated using a MMRM model with treatment, region, baseline disease severity (IGA), visit, and treatment-by-visit-interaction as fixed categorical effects and baseline and baseline-by- visit-interaction as fixed continuous effects.Change From Baseline in Skin Pain NRS Baseline, 16 Weeks Skin Pain NRS is a participant-administered, 11-point horizontal scale anchored at 0 and 10, with 0 representing "no pain" and 10 representing "worst pain imaginable." Overall severity of a participant's skin pain is indicated by selecting the number, using a daily diary, that best describes the worst level of skin pain in the past 24 hours.
LSMean was calculated using MMRM model with treatment, region, baseline disease severity (IGA), visit, and treatment-by-visit-interaction as fixed categorical effects and baseline and baseline-by-visit-interaction as fixed continuous effects.Percentage of Participants Achieving EASI50 16 Weeks The EASI assesses objective physician estimates of 2 dimensions of atopic dermatitis - disease extent and clinical signs affected: 0 = 0%; 1 = 1-9%; 2 = 10-29%; 3 = 30-49%; 4 = 50-69%; 5 = 70-89%; 6 = 90-100% and the severity of 4 clinical signs (1) erythema, (2)edema/papulation, (3) excoriation, and (4) lichenification each on a scale of 0 to 3 (0 = none, absent; 1 = mild; 2 = moderate; 3 = severe) at 4 body sites (head/neck, trunk, upper limbs, and lower limbs). Half scores are allowed between severities 1, 2 and 3. The final EASI score was obtained by weight-averaging these 4 scores and will range from 0 to 72 (severe). The EASI 50 is defined as ≥50% improvement from baseline in EASI score.
Percentage of Participants Achieving IGA of 0 16 Weeks The IGA measures the investigator's global assessment of the participants overall severity of their AD, based on a static, numeric 5-point scale from 0 (clear skin) to 4 (severe disease). The score is based on an overall assessment of the degree of erythema, papulation/induration, oozing/crusting, and lichenification.
Percentage of Participants Achieving Eczema Area and Severity Index 75 (EASI75) 16 Weeks The EASI assesses objective physician estimates of 2 dimensions of atopic dermatitis - disease extent and clinical signs affected: 0 = 0%; 1 = 1-9%; 2 = 10-29%; 3 = 30-49%; 4 = 50-69%; 5 = 70-89%; 6 = 90-100% and the severity of 4 clinical signs (1) erythema, (2) edema/papulation, (3) excoriation, and (4) lichenification each on a scale of 0 to 3 (0 = none, absent; 1 = mild; 2 = moderate; 3 = severe) at 4 body sites (head/neck, trunk, upper limbs, and lower limbs). Half scores are allowed between severities 1, 2 and 3. The final EASI score is obtained by weight-averaging these 4 scores and will range from 0 to 72 (severe). The EASI75 is defined as a ≥ 75% improvement from baseline in the EASI score.
Percent Change From Baseline on EASI Score Baseline, 16 Weeks The EASI assesses objective physician estimates of 2 dimensions of AD - disease extent and clinical signs affected: 0 = 0%; 1 = 1-9%; 2 = 10-29%; 3 = 30-49%; 4 = 50-69%; 5 = 70-89%; 6 = 90-100% and the severity of 4 clinical signs (1) erythema (2)edema/papulation, (3) excoriation, and (4) lichenification each on a scale of 0 to 3 (0 = none, absent; 1 = mild; 2 = moderate; 3 = severe) at 4 body sites (head/neck, trunk, upper limbs, and lower limbs). Half scores are allowed between severities 1, 2 and 3. The final EASI score is obtained by weight-averaging these 4 scores and will range from 0 to 72 (severe).
Least Square (LS) Means were calculated using a mixed model repeated measures (MMRM) model with treatment, region, baseline disease severity (IGA), visit, and treatment-by-visit-interaction as fixed categorical effects and baseline and baseline-by-visit-interaction as fixed continuous effects.Change From Baseline in SCORAD Baseline, 16 Weeks The SCORAD index uses the rule of nines to assess disease extent and evaluates 6 clinical characteristics to determine disease severity: (1) erythema, (2) edema/papulation, (3) oozing/crusts, (4) excoriation, (5) lichenification, and (6) dryness on a scale of 0 to 3 (0=absence, 1=mild, 2=moderate, 3=severe). The SCORAD index also assesses subjective symptoms of pruritus and sleep loss with VAS where 0 is no itching or no trouble sleeping and 10 is unbearable itching or lot of trouble sleeping. These 3 aspects: extent of disease (A: 0-1-2), disease severity (B: 0-18), \& subjective symptoms (C: 0-20) combine using A/5 + 7\*B/2+ C to give a maximum possible score of 103, where 0 = no disease and 103 = severe disease. LSMeans was calculated using MMRM model with treatment, region, baseline disease severity (IGA), visit, \& treatment-by-visit-interaction as fixed categorical effects. Baseline and baseline-by-visit-interaction as fixed continuous effects.
Percentage of Participants Achieving SCORAD90 16 Weeks The SCORAD index uses the rule of nines to assess disease extent and evaluates 6 clinical characteristics to determine disease severity: (1) erythema, (2) edema/papulation, (3) oozing/crusts, (4) excoriation, (5) lichenification, and (6) dryness on a scale of 0 to 3 (0=absence, 1=mild, 2=moderate, 3=severe). The SCORAD index also assesses subjective symptoms of pruritus and sleep loss with VAS where 0 is no itching or no trouble sleeping and 10 is unbearable itching or lot of trouble sleeping. These 3 aspects: extent of disease (A: 0-1-2), disease severity (B: 0-18), \& subjective symptoms (C: 0-20) combine using A/5 + 7\*B/2+ C to give a maximum possible score of 103, where 0 = no disease and 103 = severe disease.
SCORAD90 defined as a ≥ 90% improvement from baseline in the SCORAD score.Percentage of Participants Developing Skin Infections Requiring Antibiotic Treatment 16 Weeks Percentage of participants developing skin infections requiring antibiotic treatment.
Percent Change From Baseline in Itch NRS Baseline, 16 Weeks The Itch NRS is a participant-administered, 11-point horizontal scale, with 0 representing "no itch" and 10 representing "worst itch imaginable." Overall severity of a participant's itching is indicated by selecting the number, using a daily diary, that best describes the worst level of itching in the past 24 hours.
LSMean were calculated using MMRM model with treatment, region, baseline disease severity (IGA), visit, \& treatment-by-visit-interaction as fixed categorical effects. Baseline and baseline-by-visit-interaction as fixed continuous effects.Change From Baseline in the Patient Global Impression of Severity-Atopic Dermatitis (PGI-S-AD) Score Baseline, 16 Weeks The PGI-S-AD asked the participant to evaluate the severity of the disease at that point in time on a single-item, 5-point scale, using a daily diary. The same category labels used in the Physician's Global Assessment were used for the PGI-S-AD, ie, "(0) no symptoms", "(1) very mild", "(2) mild" "(3) moderate", and "(4) severe." LS Means were calculated using a MMRM model with treatment, region, baseline disease severity (IGA), visit, and treatment-by-visit-interaction as fixed categorical effects and baseline and baseline-by-visit-interaction as fixed continuous effects.
Change From Baseline on the Hospital Anxiety and Depression Scale (HADS) Baseline, 16 Weeks The HADS is a participant-rated instrument used to assess both anxiety and depression. This instrument consists of 14 items questionnaire, each item is rated on a 4-point scale, giving maximum scores of 21 for anxiety and depression. Scores of 11 or more on either subscale are considered to be a significant 'case' of psychological morbidity, while scores of 8-10 represent 'borderline' and 0-7, 'normal.
LSMean were calculated using MMRM model with treatment, region, baseline disease severity (IGA), visit, \& treatment-by-visit-interaction as fixed categorical effects. Baseline and baseline-by-visit-interaction as fixed continuous effects.Change From Baseline on the Dermatology Life Quality Index (DLQI) Baseline, 16 Weeks The DLQI is a simple, participant-administered, 10 question, validated, quality-of-life questionnaire that covers 6 domains: symptoms and feelings, daily activities, leisure, work and school, personal relationships, and treatment. The recall period of this scale is over the last "week." Response categories include "not at all," "a lot," and "very much," with corresponding scores of 1, 2, and 3, respectively, and unanswered ("not relevant") responses scored as "0." Scores range from 0 to 30 (less to more impairment), and a 4-point change from baseline is considered as the minimal clinically important difference threshold.
LSMean were calculated using MMRM model with treatment, region, baseline disease severity (IGA), visit, \& treatment-by-visit-interaction as fixed categorical effects. Baseline and baseline-by-visit-interaction as fixed continuous effects.Change From Baseline on the European Quality of Life-5 Dimensions 5 Levels (EQ-5D-5L) Visual Analog Score (VAS) Baseline, 16 Weeks EQ-5D-5L is a 2-part measurement. The second part is assessed using a visual analog scale (VAS) that ranged from 0 to 100 millimeter (mm), where 0 is the worst health you can imagine and 100 is the best health you can imagine.
LSMean were calculated using MMRM model with treatment, region, baseline disease severity (IGA), visit, \& treatment-by-visit-interaction as fixed categorical effects. Baseline and baseline-by-visit-interaction as fixed continuous effects.Change From Baseline in Body Surface Area (BSA) Affected Baseline, 16 Weeks Body surface area affected by AD will be assessed for 4 separate body regions and is collected as part of the EASI assessment: head and neck, trunk (including genital region), upper extremities, and lower extremities (including the buttocks). Each body region will be assessed for disease extent ranging from 0% to 100% involvement. The overall total percentage will be reported based off of all 4 body regions combined, after applying specific multipliers to the different body regions to account for the percent of the total BSA represented by each of the 4 regions.
Use the percentage of skin affected for each region (0 to 100%) in EASI as follows:
BSA Total = 0.1\*BSAhead and neck + 0.3\*BSAtrunk + 0.2\* BSAupper limbs + 0.4\*BSAlower limbs.
LSMean were calculated using MMRM model with treatment, region, baseline disease severity (IGA), visit, and treatment-by-visit-interaction as fixed categorical effects and baseline and baseline-by-visit-interaction as fixed continuous effects.Change From Baseline on the European Quality of Life-5 Dimensions 5 Levels (EQ-5D-5L) Index Score United States and United Kingdom Algorithm Baseline, 16 Weeks EQ-5D-5L is a 2-part measurement. The first part is comprised of the following 5 participant-reported dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. Each dimension has 5 levels: no problems, slight problems, moderate problems, severe problems, and extreme problems. The responses are used to derive the health state index scores using the United Kingdom (UK) algorithm, with scores ranging from -0.594 to 1, and the United States (US) algorithm, with scores ranging from -0.109 to 1. A higher score indicates better health state.
LSMean were calculated using MMRM model with treatment, region, baseline disease severity (IGA), visit, \& treatment-by-visit-interaction as fixed categorical effects. Baseline and baseline-by-visit-interaction as fixed continuous effects.Percentage of Participants Achieving Investigator's Global Assessment (IGA) of 0 or 1 With a ≥ 2 Point Improvement 4 Weeks The IGA measures the investigator's global assessment of the participants overall severity of their AD, based on a static, numeric 5-point scale from 0 (clear skin) to 4 (severe disease). The score is based on an overall assessment of the degree of erythema, papulation/induration, oozing/crusting, and lichenification.
Change From Baseline in the Total Score of the Patient Oriented Eczema Measure (POEM) Baseline, 16 Weeks The POEM is a 7-item self-assessment questionnaire that assesses disease symptoms (dryness, itching, flaking, cracking, sleep loss, bleeding and weeping) on a scale ranging from 0-4 (0 = no days, 1 = 1-2 days, 2 = 3-4 days, 3 = 5-6 days, 4 = everyday). The sum of the 7 items gives the total POEM score of 0 (absent disease) to 28 (severe disease). High scores are indicative of more severe disease and poor quality of life.
LSMean were calculated using MMRM model with treatment, region, baseline disease severity (IGA), visit, \& treatment-by-visit-interaction as fixed categorical effects. Baseline and baseline-by-visit-interaction as fixed continuous effects.Change From Baseline on the Work Productivity and Activity Impairment - Atopic Dermatitis (WPAI-AD) Questionnaire Baseline, 16 Weeks The WPAI-AD participant questionnaire was developed to measure the effect of general health and symptom severity on work productivity and regular activities in the 7 days prior to the visit. The WPAI-AD consists of 6 items grouped in 4 domains: absenteeism (work time missed), presenteeism (impairment at work/reduced on-the-job effectiveness), work productivity loss (overall work impairment/absenteeism plus presenteeism), and activity impairment, that range from 0% to 100%, with higher values indicating greater impairment. LSMean were calculated using MMRM model with treatment, region, baseline disease severity (IGA), visit, \& treatment-by-visit-interaction as fixed categorical effects. Baseline and baseline-by-visit-interaction as fixed continuous effects.
Trial Locations
- Locations (80)
Oroshaza Varosi Onkormanyzat Korhaza
🇭🇺Oroshaza, Hungary
Nomura Dermatology Clinic
🇯🇵Yokohama-shi, Kanagawa, Japan
Yamate Dermatological Clinic
🇯🇵Shinjuku, Tokyo, Japan
Clinical Trials SA Pty Ltd
🇦🇺Adelaide, South Australia, Australia
Tokyo Teishin Hospital
🇯🇵Chiyoda-Ku, Tokyo, Japan
Centro de Investigaciones Metabólicas (CINME)
🇦🇷Ciudad Autonoma de Buenos Aire, Buenos Aires, Argentina
CENIT Centro de Neurociencias, Investigación y Tratamiento
🇦🇷Caba, Buenos Aires, Argentina
Fundacion CIDEA
🇦🇷Buenos Aires, Argentina
Instituto de Neumonología y Dermatología
🇦🇷Buenos Aires, Argentina
Clinica Adventista de Belgrano
🇦🇷Ciudad de Buenos Aires, Buenos Aires, Argentina
Psoriahue Medicina Interdisciplinaria
🇦🇷Buenos Aires, Argentina
Parra Dermatología
🇦🇷Mendoza, Argentina
Skin & Cancer Foundation Australia
🇦🇺Westmead, New South Wales, Australia
Buenos Aires Skin
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
AKH
🇦🇹Wien, Austria
Veracity Clinical Research Pty Ltd
🇦🇺Woolloongabba, Queensland, Australia
Ordensklinikum Linz GmbH - Elisabethinen
🇦🇹Linz, Oberösterreich, Austria
Skin and Cancer Foundation Inc.
🇦🇺Carlton, Victoria, Australia
Fremantle Dermatology
🇦🇺Perth, Western Australia, Australia
KA Rudolfstiftung
🇦🇹Wien, Austria
KH Hietzing mit neurologischem Zentrum Rosenhügel
🇦🇹Wien, Austria
Debreceni Egyetem Klinikai Kozpont Borgyogyaszati Klinika
🇭🇺Debrecen, Hajdu-Bihar, Hungary
Sozialmed. Zentrum Ost - Donauspital
🇦🇹Wien, Austria
Trial Pharma Kft.
🇭🇺Puspokladany, Hajdu-Bihar, Hungary
Markusovszky Korhaz
🇭🇺Szombathely, Hungary
UNO Medical Trials Kft.
🇭🇺Budapest, Hungary
Haemek Medical Center- Dermatology
🇮🇱Afula, Israel
Sheba Medical Center
🇮🇱Ramat Gan, Israel
Rambam Medical Center
🇮🇱Haifa, Israel
Hadassah Medical Center - Ein Karem
🇮🇱Jerusalem, Israel
Rabin Medical Center
🇮🇱Petach Tikva, Israel
Yanagihara dermatology clinic
🇯🇵Ainokawa, Ichikawa-shi, Chiba, Japan
Kurume University Hospital
🇯🇵Kurume, Fukuoka, Japan
Tel Aviv Sourasky Medical Center
🇮🇱Tel Aviv, Israel
Noguchi Dermatology
🇯🇵Kashima-machi, Kamimashiki-gun, Kumamoto, Japan
Sapporo Skin Clinic
🇯🇵Sapporo, Hokkaido, Japan
Tokyo Medical University Ibaraki Medical Center
🇯🇵Inashiki-gun, Ibaraki, Japan
Osaka Habikino Medical Center
🇯🇵Habikino, Osaka, Japan
Yoshioka Dermatology Clinic
🇯🇵Neyagawa-shi, Osaka, Japan
Sanrui Dermatology Clinic
🇯🇵Ohmiya-ku,Saitama-shi, Saitama, Japan
Jichi Medical University Hospital
🇯🇵Shimotsuke, Tochigi, Japan
Naoko Dermatology Clinic
🇯🇵Setagaya-ku, Tokyo, Japan
Tachikawa Dermatology Clinic
🇯🇵Tachikawa-shi, Tokyo, Japan
Gifu University Hospital
🇯🇵Gifu, Japan
Osaka City University Hospital
🇯🇵Osaka, Japan
Ajou University Hospital
🇰🇷Suwon, Gyeonggi Do, Korea, Republic of
Severance Hospital Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
Gachon University Gil Medical Center
🇰🇷Incheon, Korea, Korea, Republic of
Konkuk University Hospital
🇰🇷Seoul, Korea, Republic of
Chungang University Hospital
🇰🇷Seoul, Korea, Republic of
Hallym University of Medicine
🇰🇷Seoul, Korea, Republic of
"Dermed" Centrum Medyczne Sp. z o.o.
🇵🇱Lodz, Poland
NZOZ Specjalistyczna Przychodnia Dermatologiczna Specderm
🇵🇱Bialystok, Poland
Centrum Badan Klinicznych, PI House
🇵🇱Gdansk, Poland
Barbara Rewerska DIAMOND CLINIC
🇵🇱Krakow, Poland
Centrum Medyczne Angelius Provita
🇵🇱Katowice, Poland
Miejski Szpital Zespolony w Olsztynie
🇵🇱Olsztyn, Poland
LASER CLINIC S.C. Dr Tomasz Kochanowski, Dr Andrzej Krolicki
🇵🇱Szczecin, Poland
DermoDent, Centrum Medyczne Czajkowscy
🇵🇱Osielsko, Poland
Wojskowy Instytut Medyczny
🇵🇱Warsaw, Poland
Centralny Szpital Kliniczny MSW
🇵🇱Warszawa, Poland
Hospital Universitario Rey Juan Carlos
🇪🇸Mostoles, Madrid, Spain
Hospital De Fuenlabrada
🇪🇸Fuenlabrada, Madrid, Spain
Clinica Universitaria De Navarra
🇪🇸Pamplona, Navarra, Spain
Hospital Germans Trias i Pujol
🇪🇸Barcelona, Badalona, Spain
Hospital General Universitario Alicante
🇪🇸Alicante, Spain
Hospital Infanta Leonor
🇪🇸Madrid, Spain
Inselspital Bern
🇨🇭Bern, Switzerland
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Hospital Universitario La Paz
🇪🇸Madrid, Spain
HUG-Hôpitaux Universitaires de Genève
🇨🇭Genève, Switzerland
CHUV Centre Hospitalier Universitaire Vaudois
🇨🇭Lausanne, Vaud, Switzerland
Centro de Especialidades Mollabao
🇪🇸Pontevedra, Spain
Universitätsspital Zürich
🇨🇭Zürich, Switzerland
Seoul St. Mary's Hospital
🇰🇷Seoul, Korea, Republic of
SZTE AOK Borgyogyaszati es Allergologiai Klinika
🇭🇺Szeged, Csongrad, Hungary
Allergo-Derm Bakos Kft
🇭🇺Szolnok, Jasz-Nagykun-Szolnok, Hungary
Kaposi Mor Oktato Korhaz
🇭🇺Kaposvar, Hungary
MedMare Bt
🇭🇺Veszprem, Hungary
Woden Dermatology
🇦🇺Phillip, Australian Capital Territory, Australia