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Comparison Between spIgE and Skin Prick Test of Local and Imported Aeroallergens

Not Applicable
Completed
Conditions
Immediate Hypersensitivity
Interventions
Procedure: Skin prick test
Other: specific IgE measurement
Registration Number
NCT02561390
Lead Sponsor
Mahidol University
Brief Summary

The prevalence of Allergic rhinitis(AR) and asthma was increased world wide. In 1998, ISAAC found that prevalence of AR and asthma inThailand was in moderately high group.

Tests for immediated reaction SPT and spIgE, were used for evaluated sensitization of allergen in patient. They guided the investigators for proper management as well as patient education. Clinician will use the result for choose allergen in case that might need immunotherapy.

SPT is safe and more economic for patient. Specific IgE has an advantage in patient who cannot withhold antihistamine prior SPT. In United state had a trial of result between SPT and spIgE for cockroach, cat, house dust mite and mold. It showed the correlation between two tests. In Thailand, the investigators haven't had data about it yet.

Detailed Description

SPT and specific IgE for allergens is necessary for allergen avoidance and specific immunotherapy. To have local allergen extracts will help the patients to easier get the appropriate management

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
84
Inclusion Criteria
  • Patient with controlled Asthma and/or AR (mild to moderate severity) who were diagnosed in Allergy clinic and ENT clinic, Siriraj hospital
  • SPT positve one of American Cockroach, House dust mite, cat, dog and mold.
  • Patient were consented to trial.
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Exclusion Criteria
  • Chronic disease such as heart disease, liver, renal and severe sepsis
  • History of anaphylaxis
  • Skin rash
  • Pregnancy
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Study & Design

Study Type
INTERVENTIONAL
Study Design
SINGLE_GROUP
Arm && Interventions
GroupInterventionDescription
Skin prick test with aeroallergensSkin prick testMean wheal diameters of SPT with commercial and local American coakroach, house dust mite, cat, dog and mold
specific IgE measurementSkin prick testspecific IgE levels of commercial and local American coakroach, house dust mite, cat, dog and mold
Skin prick test with aeroallergensspecific IgE measurementMean wheal diameters of SPT with commercial and local American coakroach, house dust mite, cat, dog and mold
specific IgE measurementspecific IgE measurementspecific IgE levels of commercial and local American coakroach, house dust mite, cat, dog and mold
Primary Outcome Measures
NameTimeMethod
mean wheal diameter of SPT of local and imported allergen extracts and specific IgE levels18 months

measure and compare SPT result of local and imported allergen extracts

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Faculty of Medicine Siriraj Hospital

🇹🇭

Bangkoknoi, Bangkok, Thailand

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