Efficacy of cranial mobilization and temporomandibular mobilization with mulligan manual therapy for reduction in salivary cortisol in individual with cervicogenic headache

The study specifically examines the relationship between cervical spine dysfunction stress biomarkers (salivary cortisol) and TMJ issues in cervicogenic headache patients addressing a comprehensive view of the condition rather than treating symptoms in isolation. The randomized controlled trial design with 168 participants and multiple assessment timepoints (Day 0, 21, and 90) provides robust evidence. The use of objective measures like Kinovea software for posture analysis and salivary cortisol testing adds scientific rigor.