NCT02297958已完成不适用
Impact of Fas/FasL in Chemotherapy Response in Epithelial Ovarian Carcinoma
Rennes University Hospital1 个研究点 分布在 1 个国家目标入组 28 人开始时间: 2015年1月15日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Correlation between cleaved FasL level ans neoadjuvant chemotherapy tumor response
研究概览
简要总结
Ovarian carcinoma has poor prognosis and new therapeutic strategies are required. Many patients with ovarian carcinoma showed resistance to chemotherapy. Cleaved FasL is known for induced atypical response when is binding to Fas such as avoiding apoptosis and inducing cell motility.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patient with suspicious ovarian carcinoma using clinical data, biological data (ca125) and radiological data (CT)
- •Inclusion Criteria:
- •Pathological ovarian carcinoma diagnosed at pathological analysis after surgery.
- •Neo adjuvant chemotherapy
排除标准
- •no neo-adjuvant chemotherapy
- •no ovarian carcinoma at final pathological analysis
- •less than 18 years old.
结局指标
主要结局
Correlation between cleaved FasL level ans neoadjuvant chemotherapy tumor response
时间窗: surgery
Main outcome is cleaved FasL level and correlation with neoadjuvant chemotherapy tumor response, evaluated during surgery.
次要结局
- Disease Free Survival rate(18 months after surgery)
- Identification of tumoral T cells(surgery)
- Overall survival rate(18 months after surgery)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Study of Predictive Factors of Chemoresistance in Ovarian CancerOvarian CancerNCT02878122Rennes University Hospital13
进行中（未招募）
不适用
Molecular Mechanisms Leading to Chemoresistance in Epithelial Ovarian CancerOvarian CancerNCT02758652Tampere University Hospital160
招募中
不适用
Overcoming Chemoresistance in Advanced Ovarian Cancer Via Targeting HypoxiaFallopian Tube CancerHypoxiaPeritoneal CarcinomaEpithelial Ovarian CancerNCT04001023Turku University Hospital40
终止
2 期
Antineoplaston Therapy in Treating Patients With Stage III or Stage IV Ovarian CancerStage III Ovarian CancerStage IV Ovarian CancerNCT00003532Burzynski Research Institute7
撤回
不适用
Influence of Chemotherapy on Gamma-delta T Cells in Patients With Epithelial Ovarian CancerOvarian CancerNCT01606358Rennes University Hospital