Predictive Value of Doppler Renal Resistive Index for Prediction of Acute Kidney Injury in Septic Patients in Intensive Care Unit.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Kidney Injury
- Sponsor
- Ain Shams University
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- incidence of AKI
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Acute kidney injury (AKI) Diagnosis is based on rising creatinine. Intrarenal vasoconstriction occurs earlier and measuring flow resistance in the renal circulation (Renal Resistive Index (RRI)) could become part of vital organ function assessment using Doppler ultrasound.
The aim of this study is to predict AKI in septic patients in ICU by measuring RRI on admission by comparing two groups of patients, first group with RRI of normal value (0.6-0.7) and the other group with high RRI more than 0.7 and both with normal renal function on admission.
Detailed Description
Patients who have criteria of sepsis, with normal renal function on admission will undergo Renal Doppler Ultrasound examination to measure Renal resistive index. Patients will be divided into 2 groups: 1. Group (A) patients with renal resistive index between 0.6 and 0.7 (normal RRI). 2. Group (B) patients with renal resistive index more than 0.7 (high RRI).
Investigators
Mohamed Saleh Ahmed Massoud
Lecturer of Anesthesia and Intensive Care
Ain Shams University
Eligibility Criteria
Inclusion Criteria
- •Patients who have criteria of sepsis on admission which include two or more of SIRS which include: (Temperature \>38°C or \<36°C, Heart rate \>90/min, Respiratory rate \>20/min or PaCO2 \<32mmHg (4.3kPa) and White blood cell count \>12000/mm3 or \<4000/mm3 or \>10% immature bands.) in addition to suspected or confirmed infection.
- •Patients who have normal renal function on admission.
Exclusion Criteria
- •Currently recovering from an AKI at the time of inclusion and Renal impairment on admission.
- •Patients with obstructive renal failure, renal artery stenosis were excluded from this study.
- •Patients on chemotherapy and/or radiotherapy.
Outcomes
Primary Outcomes
incidence of AKI
Time Frame: 1 day at admission
incidence of AKI related to Renal resistive index.
Secondary Outcomes
- APACHE IV score(1 day at admission)
- APACHE III score(1 day at admission)
- SOFA score(1 day at admission)