Predictive Value of Doppler Renal Resistive Index for Prediction of Acute Kidney Injury in Septic Patients in Intensive Care Unit.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- incidence of AKI
研究概览
简要总结
Acute kidney injury (AKI) Diagnosis is based on rising creatinine. Intrarenal vasoconstriction occurs earlier and measuring flow resistance in the renal circulation (Renal Resistive Index (RRI)) could become part of vital organ function assessment using Doppler ultrasound.
The aim of this study is to predict AKI in septic patients in ICU by measuring RRI on admission by comparing two groups of patients, first group with RRI of normal value (0.6-0.7) and the other group with high RRI more than 0.7 and both with normal renal function on admission.
详细描述
Patients who have criteria of sepsis, with normal renal function on admission will undergo Renal Doppler Ultrasound examination to measure Renal resistive index.
Patients will be divided into 2 groups:
- Group (A) patients with renal resistive index between 0.6 and 0.7 (normal RRI).
- Group (B) patients with renal resistive index more than 0.7 (high RRI).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who have criteria of sepsis on admission which include two or more of SIRS which include: (Temperature >38°C or <36°C, Heart rate >90/min, Respiratory rate >20/min or PaCO2 <32mmHg (4.3kPa) and White blood cell count >12000/mm3 or <4000/mm3 or >10% immature bands.) in addition to suspected or confirmed infection.
- •Patients who have normal renal function on admission.
排除标准
- •Currently recovering from an AKI at the time of inclusion and Renal impairment on admission.
- •Patients with obstructive renal failure, renal artery stenosis were excluded from this study.
- •Patients on chemotherapy and/or radiotherapy.
结局指标
主要结局
incidence of AKI
时间窗: 1 day at admission
incidence of AKI related to Renal resistive index.
次要结局
- APACHE IV score(1 day at admission)
- APACHE III score(1 day at admission)
- SOFA score(1 day at admission)
研究者
Mohamed Saleh Ahmed Massoud
Lecturer of Anesthesia and Intensive Care
Ain Shams University