Pilot study to validate scRNA sequencing and CyTOF analysis in intestinal biopsies from patients with inflammatory bowel disease
Recruiting
- Conditions
- Inflammatory bowel disease10017969
- Registration Number
- NL-OMON51051
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
All adult patients (*18y/o) with legal capacities and a diagnosis of IBD (CD or
ulcerative colitis) undergoing a standardized care follow-up colonoscopy can be
enrolled after giving written informed consent to enrolment.
Exclusion Criteria
Patients are not eligible to participate when they have an ongoing malignancy,
history of previous colonic surgery or serious concomitant inflammatory
diseases and/or anti-inflammatory treatment(s) that may impair the
interpretability of the biomarker analysis, per investigators* interpretation.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>We hypothesize that with the mentioned biopsies we will acquire around 500.000<br /><br>viable cells required for thorough analysis with scRNAseq and CyTOF analysis.</p><br>
- Secondary Outcome Measures
Name Time Method <p>na</p><br>