Diltiazem Gel or Ointment, Which One is a Better Choice for Anal Fissure?

Phase 3

Recruiting

• Conditions: Anal fissure.; Anal fissure; K60.2

• Registration Number: IRCT20141116019971N5
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-02-22

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

Symptoms of anal fissure (pain, bleeding, burning, or itching) in the last six weeks.
Finding one of the following signs on examination: visible sphincter fibers at the fissure base, anal papillae, sentinel piles, and indurated margins.

Exclusion Criteria

Past history of anal surgery
Current consumption of other topical or oral medication for anal fissure.
History of allergic reaction to diltiazem.
History of cardiovascular problems including sick sinus syndrome, heart block, arrhythmia, bradycardia, heart failure, and cardiomyopathy.
Hypotension (systolic blood pressure < 90 mmHg).
History of chronic liver failure.
Current consumption of antihypertensive drugs.
Pregnancy and breast feeding.
Failure to obtain informed consent.

Study & Design

• Study Type: interventional
• Study Design: Not specified