Randomised study of neurocognitive outcome and cerebral embolic events in patients undergoing off-pump and on-pump coronary artery bypass graft surgery
Not Applicable
Completed
- Conditions
- eurocognitive dysfunctionNervous System DiseasesNeurocognitive dysfunction
- Registration Number
- ISRCTN97967360
- Lead Sponsor
- St George's Hospital (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 0
Inclusion Criteria
Patients undergoing first time elective coronary artery bypass surgery.
Exclusion Criteria
1. Previous cerebrovascular accident or Transient Ischaemic Attack (TIA)
2. Right or left internal carotid artery stenosis more than or equal to 50%
3. Previous cardiac surgery
4. Concomitant surgery, e.g. valve replacement
5. Previous psychiatric illness, e.g. depression, schizophrenia
6. Dialysis-dependent renal failure
7. Q-wave myocardial infarction in the past six weeks
8. Very poor left ventricular function (ejection fraction less than 20%)
9. Illiteracy or non-fluency in English
10. Absence of an acoustic window for transcranial Doppler ultrasound monitoring
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Post-operative composite neurocognitive score at six months and three years.
- Secondary Outcome Measures
Name Time Method The neurocognitive score at discharge and at six weeks, and the total intra-operative microemboli count.