Use of Mini-fluid Challenge for Fluid Responsiveness Prediction During One-lung Ventilation

Completed

• Conditions: Acute Circulatory Failure During One-lung Ventilation Surgery
• Interventions: Other: Fluid challenge; Other: Trans-oesophageal echography

• Registration Number: NCT02858115
• Lead Sponsor: Assistance Publique Hopitaux De Marseille

Brief Summary

During thoracic surgery, an excessive use of fluid results in pulmonary complications. Dynamic fluid responsiveness predictors are not easily usable during one lung ventilation. The investigators hypothesized that the assessment by transesophageal echocardiography (TEE) of subaortic velocity time index (VTI) variation after 100 ml of crystalloid would predict fluid responsiveness in patients receiving one-lung ventilation.

This retrospective, observational, single center study was from January 2014 to December 2015. The investigators included 105 patients requiring one lung ventilation lung resection. The investigators analysed 39 patients presenting an acute circulatory failure. 100 ml of crystalloid was infused over 1-min. After an echocardiographic assessment at 1-min, remaining 400 ml were administered over 14-min Fluid responsiveness was defined as an increase in the VTI above 15% after infusion of 500 ml of crystalloid.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-01
• Primary Completion: 2015-12
• Status Verified: 2016-08
• Study Completion: 2016-08
• Study First Submitted: 2016-08-03
• Study First Submitted QC: 2016-08-05
• Last Update Submitted: 2016-08-05
• Study First Posted: 2016-08-08
• Last Update Posted: 2016-08-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Lung resection
• Acute circulatory failure
• One-lung ventilation

Exclusion Criteria

• Sinusal rhythm

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
one lung ventilation lung	Fluid challenge	patients requiring one lung ventilation lung resection.
one lung ventilation lung	Trans-oesophageal echography	patients requiring one lung ventilation lung resection.

Primary Outcome Measures

Name	Time	Method
Velocity time index	one day	: Echographic assesment of cardiac output
Fluid responsiveness	one day	increase of cardiac output of more than 15%

Secondary Outcome Measures

Name	Time	Method
Pulsed pressure variation	one day	dynamic indice of fluid responsiveness

Trial Locations

Locations (1)

hôpital Nord Assistance Publique Hôpitaux de Marseille; 🇫🇷 Marseille, France