Modulation of Matrix Metalloproteinases-8, -9 and Endogenous Tissue Inhibitor-1 in Oral Biofluids During Pregnancy and Postpartum
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 114
- 主要终点
- Changing MMP-9 levels
研究概览
简要总结
The aim of this study was to investigate salivary and gingival crevicular fluid (GCF) levels of MMP-8, MMP-9 and TIMP-1 during 2/3 trimester of pregnancy and after delivery
详细描述
MMP-8 and MMP-9 have been reported to reflect the inflammatory status in periodontal tissues and, therefore represent as potential biomarkers of periodontitis. The balance between tissue inhibitors of metalloproteinases (TIMPs) and MMPs play an important role in maintaining the integrity of healthy periodontium.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Pregnant group included women, who were in their second trimester (weeks 16-24) and third trimester (weeks 25-34)
排除标准
- •(a) any known systemic disease, (b) periodontal treatment within the last six months, (c) patients having less than 10 teeth, (d) smokers and (e) individuals with BMI > 30 kg/m2
结局指标
主要结局
Changing MMP-9 levels
时间窗: 6 months
Salivary and GCF level measured by ELISA
Changing TIMP-1 levels
时间窗: 6 months
Salivary and GCF level measured by ELISA
Changing MMP-8 levels
时间窗: 6 months
Salivary and GCF level measured by IFMA
次要结局
未报告次要终点
研究者
Veli Özgen Öztürk
Principal Investigator
Aydin Adnan Menderes University