Prokinetic Drugs and Enteral Nutrition

• Conditions: Critically Ill; Enteral Nutrition

• Registration Number: NCT00916591
• Lead Sponsor: Universitair Ziekenhuis Brussel

Brief Summary

The purpose of this study is to compare the effect of two drugs that can help in the prevention of regurgitation during the administration of enteral nutrition and define which one is the most effective.

Detailed Description

Two prokinetic drugs (metoclopramide and erythromycin) will be compared during the administration of enteral nutrition in critically ill patients. We would like to know which one is the most effective in preventing regurgitation and risk of aspiration, which is a common complication of enteral nutritional support. This will be evaluated by measuring gastric residue every six hours.

Study Timeline

• Status Verified: 2009-06
• Study First Submitted: 2009-06-05
• Study First Submitted QC: 2009-06-05
• Last Update Submitted: 2009-06-05
• Study First Posted: 2009-06-09
• Last Update Posted: 2009-06-09
• Study Start: 2009-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• critically ill patients
• intubated
• mechanically ventilated
• 18 or older age
• enterally fed

Exclusion Criteria

• prokinetic drugs before start study
• allergy to study medication
• interactions odf study medication with other drugs
• recent gastro-intestinal surgery
• history of esophagectomy or gastrectomy
• suspicion of gastrointestinal perforation
• myasthenia gravis
• liver dysfunction
• less than 7 days in study
• gastro- or jejunostomy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

UZBrussels; 🇧🇪 Jette, Belgium