Effects of Morphine Added to Bupivacaine in Transversus Abdominis Plane Block for Inguinal Hernia Repair

Not Applicable

Completed

• Conditions: Inguinal Hernia
• Interventions: Combination Product: bupivacaine and morphine

• Registration Number: NCT05379374
• Lead Sponsor: B.P. Koirala Institute of Health Sciences

Brief Summary

This study is conducted to determine whether morphine added to bupivacaine in ultrasound guided (USG) transversus abdominis plane (TAP) block has beneficial effects than bupivacaine alone in providing postoperative analgesia for inguinal hernia surgery.

Detailed Description

Total of forty adult patients of American Society of Anaesthesiologists (ASA) physical status ( PS) I - II scheduled for elective inguinal hernia surgery under spinal anaesthesia were recruited in this study after getting written informed consent. They were randomized to undergo ipsilateral USG TAP block with 20 ml of 0.25 % bupivacaine (group B) versus 20 ml of 0.25 % bupivacaine with 3 mg morphine (group BM). Patients were followed postoperatively for the 24 hours by a blinded investigator for monitoring of number of rescue analgesic consumed, duration of analgesia, numerical rating scale (NRS) at rest and on cough and any adverse effects.

Study Timeline

• Study Start: 2018-08-18
• Primary Completion: 2020-01-20
• Study Completion: 2020-01-20
• Status Verified: 2022-05
• Study First Submitted: 2022-05-13
• Study First Submitted QC: 2022-05-17
• Last Update Submitted: 2022-05-17
• Study First Posted: 2022-05-18
• Last Update Posted: 2022-05-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

ASA I to III Elective surgery

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Exclusion Criteria

• Patient's refusal
• BMI > 35 kg/m2 or < 18 kg/m2
• Allergic or contraindication to drugs used in study
• Coagulopathy
• Local site infection
• Spine deformity
• Uncooperative or psychological illness
• Inability to comprehend pain scale
• Drugs not injected in target area

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Bupivacaine group	bupivacaine and morphine	0.25% bupivacaine 20 ml in TAP block
Bupivacaine morphine group	bupivacaine and morphine	0.25% bupivacaine 20 ml with 3 mg morphine in TAP block

Primary Outcome Measures

Name	Time	Method
• Duration of postoperative analgesia • Postoperative analgesic requirement	Till 24 hour after surgery	Time from TAP block to first request of analgesic is considered as duration of analgesia Less requirement of rescue analgesic is considered as better

Secondary Outcome Measures

Name	Time	Method
• NRS for pain at rest and on cough between the groups • Any side effects	Till 24 hour after surgery	Group with higher NRS score is considered a less effective Group with increase side effects is considered as not acceptable

Trial Locations

Locations (1)

Purna kala Gurung; 🇳🇵 Dharān Bāzār, Province No. 1, Nepal