Comparison of Analgesic Effects of Ultrasound Guided Transversus Abdominis Plane Block With Bupivacaine and Bupivacaine With Morphine in Patient Undergoing Open Unilateral Inguinal Hernia Repair Under Spinal Anaesthesia
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- • Duration of postoperative analgesia • Postoperative analgesic requirement
Study Overview
Brief Summary
This study is conducted to determine whether morphine added to bupivacaine in ultrasound guided (USG) transversus abdominis plane (TAP) block has beneficial effects than bupivacaine alone in providing postoperative analgesia for inguinal hernia surgery.
Detailed Description
Total of forty adult patients of American Society of Anaesthesiologists (ASA) physical status ( PS) I - II scheduled for elective inguinal hernia surgery under spinal anaesthesia were recruited in this study after getting written informed consent. They were randomized to undergo ipsilateral USG TAP block with 20 ml of 0.25 % bupivacaine (group B) versus 20 ml of 0.25 % bupivacaine with 3 mg morphine (group BM). Patients were followed postoperatively for the 24 hours by a blinded investigator for monitoring of number of rescue analgesic consumed, duration of analgesia, numerical rating scale (NRS) at rest and on cough and any adverse effects.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Masking Description
- Anaesthetic technician will prepare the study drug
- Anaesthesiologist who is blind to the study drug will perform UG TAP block and collect data intra and post-operatively.
- Patient will also be blind about the drug administered.
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •ASA I to III Elective surgery
Exclusion Criteria
- •Patient's refusal
- •BMI > 35 kg/m2 or < 18 kg/m2
- •Allergic or contraindication to drugs used in study
- •Coagulopathy
- •Local site infection
- •Spine deformity
- •Uncooperative or psychological illness
- •Inability to comprehend pain scale
- •Drugs not injected in target area
Arms & Interventions
Bupivacaine group
0.25% bupivacaine 20 ml in TAP block
Intervention: bupivacaine and morphine (Combination Product)
Bupivacaine morphine group
0.25% bupivacaine 20 ml with 3 mg morphine in TAP block
Intervention: bupivacaine and morphine (Combination Product)
Outcomes
Primary Outcomes
• Duration of postoperative analgesia • Postoperative analgesic requirement
Time Frame: Till 24 hour after surgery
Time from TAP block to first request of analgesic is considered as duration of analgesia Less requirement of rescue analgesic is considered as better
Secondary Outcomes
- • NRS for pain at rest and on cough between the groups • Any side effects(Till 24 hour after surgery)
Investigators
Purna Kala Gurung
Principal Investigator ( Assistant Professor)
B.P. Koirala Institute of Health Sciences