Cardiovascular Health Effects of Flavanol Rich Chocolate

Wageningen University1 site in 1 country44 target enrollmentJanuary 2011

ConditionsEndothelial Dysfunction

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Endothelial Dysfunction
Sponsor: Wageningen University
Enrollment: 44
Locations: 1
Primary Endpoint: Blood pressure
Status: Completed
Last Updated: 14 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

In the CHOC study the investigators will examine the effect of chocolate flavanols on vascular function, inflammation, oxidative stress and markers of endothelial function. The effects of both acute consumption and prolonged consumption will be studied. The secondary objectives are to investigate if daily intake of chocolate flavanols for 4 weeks will improve the response to a high fat/high energy challenge.

Registry

clinicaltrials.gov

Start Date

January 2011

End Date

June 2011

Last Updated

14 years ago

Study Type

Interventional

Study Design

Crossover

Sex

Male

Investigators

Sponsor

Wageningen University

Eligibility Criteria

Inclusion Criteria

•45-70 years old
•BMI between 25 and 32 kg/m2

Exclusion Criteria

•Urine glucose concentrations outside normal ranges (\> 0,25 g/l)
•Fasting blood glucose \< 7.0 mmol/L)
•Systolic Bp \> 160 mmHg or diastolic Bp \> 100 mmHg
•Blood Hb values below 8.4 mmol/L
•Allergic to cow milk, dairy products or chocolate
•Vegetarian
•Tobacco smoker
•Diagnosed with any long-term medical condition (e.g., diabetes, hemophilia, cardiovascular disease, anemia, gastrointestinal disease, renal failure)