NCT01308892已完成不适用
Cardiovascular Health Effects of Flavanol Rich Chocolate
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 44
- 试验地点
- 2
- 主要终点
- Blood pressure
研究概览
简要总结
In the CHOC study the investigators will examine the effect of chocolate flavanols on vascular function, inflammation, oxidative stress and markers of endothelial function. The effects of both acute consumption and prolonged consumption will be studied. The secondary objectives are to investigate if daily intake of chocolate flavanols for 4 weeks will improve the response to a high fat/high energy challenge.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 45 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •45-70 years old
- •BMI between 25 and 32 kg/m2
排除标准
- •Urine glucose concentrations outside normal ranges (> 0,25 g/l)
- •Fasting blood glucose < 7.0 mmol/L)
- •Systolic Bp > 160 mmHg or diastolic Bp > 100 mmHg
- •Blood Hb values below 8.4 mmol/L
- •Allergic to cow milk, dairy products or chocolate
- •Vegetarian
- •Tobacco smoker
- •Diagnosed with any long-term medical condition (e.g., diabetes, hemophilia, cardiovascular disease, anemia, gastrointestinal disease, renal failure)
结局指标
主要结局
Blood pressure
时间窗: 0, 4wk
FMD
时间窗: 0, 4wk
PWA
时间窗: 0, 4wk
次要结局
- leukocyte count and activation(0, 4wk)
- PBMC gene expression(0 and 2 hrs)
- Markers of inflammation and ED(0, 4wk)
- Blood pressure(0 and 2h)
- FMD(0 and 2hrs)
- PWA(0 and 2 hrs)
- Leukocyte count and activation(0 and 2 hrs)
- markers of inflammation and ED(0 and 2hrs)
研究者
研究点 (2)
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