Cardiovascular Health Effects of Flavanol Rich Chocolate
Not Applicable
Completed
- Conditions
- Endothelial Dysfunction
- Registration Number
- NCT01308892
- Lead Sponsor
- Wageningen University
- Brief Summary
In the CHOC study the investigators will examine the effect of chocolate flavanols on vascular function, inflammation, oxidative stress and markers of endothelial function. The effects of both acute consumption and prolonged consumption will be studied. The secondary objectives are to investigate if daily intake of chocolate flavanols for 4 weeks will improve the response to a high fat/high energy challenge.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 44
Inclusion Criteria
- Male
- 45-70 years old
- BMI between 25 and 32 kg/m2
Exclusion Criteria
- Urine glucose concentrations outside normal ranges (> 0,25 g/l)
- Fasting blood glucose < 7.0 mmol/L)
- Systolic Bp > 160 mmHg or diastolic Bp > 100 mmHg
- Blood Hb values below 8.4 mmol/L
- Allergic to cow milk, dairy products or chocolate
- Vegetarian
- Tobacco smoker
- Diagnosed with any long-term medical condition (e.g., diabetes, hemophilia, cardiovascular disease, anemia, gastrointestinal disease, renal failure)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Blood pressure 0, 4wk FMD 0, 4wk PWA 0, 4wk
- Secondary Outcome Measures
Name Time Method leukocyte count and activation 0, 4wk PBMC gene expression 0 and 2 hrs acute study part
Markers of inflammation and ED 0, 4wk Blood pressure 0 and 2h acute study part
FMD 0 and 2hrs acute study part
PWA 0 and 2 hrs acute study part
Leukocyte count and activation 0 and 2 hrs acute study part
markers of inflammation and ED 0 and 2hrs acute study part
Trial Locations
- Locations (1)
Wageningen universiteit division of human
🇳🇱Wageningen, Gelderland, Netherlands
Wageningen universiteit division of human🇳🇱Wageningen, Gelderland, Netherlands