fMRI and TMS Analysis of Cerebellar Cognitive Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 17
- 试验地点
- 2
- 主要终点
- Behavioral performance (accuracy, or rate of conditioned responses)
研究概览
简要总结
Functional neuroimaging studies have shown that the cerebellum is active during cognitive performance. The investigators hypothesize that stimulation of the cerebellum with transcranial magnetic stimulation will produce brief changes in performance of the task, suggesting that cerebellar activation is necessary for normal cognitive function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 19 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •19-30 years of age
- •Informed consent
排除标准
- •History of seizure or a family history of epilepsy
- •History of stroke
- •Presence of metal anywhere in the head except the mouth
- •Presence of cardiac pacemakers
- •Presence of cochlear implants
- •Presence of implanted medication pump
- •History of heart disease
- •Presence of intracardiac lines
- •Increased intracranial pressure, such as after infarctions or trauma
- •Children, or outside of age range
- •Pregnancy
- •Currently taking tricyclic anti-depressants or neuroleptic medication
- •History of head trauma
- •History of respiratory disease
研究组 & 干预措施
Sham TMS
A Sham TMS coil, designed to elicit sham cerebellar transcranial magnetic stimulation, is used to administer sham TMS pulses after letters are presented.
干预措施: Cerebellar transcranial magnetic stimulation (Device)
TMS
A genuine TMS coil is used to administer cerebellar transcranial magnetic stimulation pulses after letter presentation.
干预措施: Cerebellar transcranial magnetic stimulation (Device)
结局指标
主要结局
Behavioral performance (accuracy, or rate of conditioned responses)
时间窗: during computerized task performance (2 hours)
次要结局
- Reaction time(during performance of computerized task (2 hours))