Effects of Transcranial Magnetic Stimulation to the Cerebellum on Cognition

Not Applicable

Completed

• Conditions: Cognitive Performance
• Interventions: Device: Cerebellar transcranial magnetic stimulation

• Registration Number: NCT00740701
• Lead Sponsor: Johns Hopkins University

Brief Summary

Functional neuroimaging studies have shown that the cerebellum is active during cognitive performance. The investigators hypothesize that stimulation of the cerebellum with transcranial magnetic stimulation will produce brief changes in performance of the task, suggesting that cerebellar activation is necessary for normal cognitive function.

Detailed Description

Not available

Study Timeline

• Study Start: 2000-04
• Primary Completion: 2005-01
• Study Completion: 2005-01
• Study First Submitted: 2008-08-22
• Study First Submitted QC: 2008-08-22
• Study First Posted: 2008-08-25
• Status Verified: 2018-08
• Last Update Submitted: 2018-08-23
• Last Update Posted: 2018-08-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 17

Inclusion Criteria

• 19-30 years of age
• Informed consent

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Exclusion Criteria

• History of seizure or a family history of epilepsy
• History of stroke
• Presence of metal anywhere in the head except the mouth
• Presence of cardiac pacemakers
• Presence of cochlear implants
• Presence of implanted medication pump
• History of heart disease
• Presence of intracardiac lines
• Increased intracranial pressure, such as after infarctions or trauma
• Children, or outside of age range
• Pregnancy
• Currently taking tricyclic anti-depressants or neuroleptic medication
• History of head trauma
• History of respiratory disease

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Sham TMS	Cerebellar transcranial magnetic stimulation	A Sham TMS coil, designed to elicit sham cerebellar transcranial magnetic stimulation, is used to administer sham TMS pulses after letters are presented.
TMS	Cerebellar transcranial magnetic stimulation	A genuine TMS coil is used to administer cerebellar transcranial magnetic stimulation pulses after letter presentation.

Primary Outcome Measures

Name	Time	Method
Behavioral performance (accuracy, or rate of conditioned responses)	during computerized task performance (2 hours)

Secondary Outcome Measures

Name	Time	Method
Reaction time	during performance of computerized task (2 hours)

Trial Locations

Locations (1)

Kennedy Krieger Institute; 🇺🇸 Baltimore, Maryland, United States