Clinical trial to compare the efficacy of two oral prokinetics metoclopramide and erythromycin in non acceptance of feed in head injury patient
- Conditions
- Health Condition 1: null- head injury
- Registration Number
- CTRI/2015/08/006111
- Lead Sponsor
- Post Graduate Institue of Medical education research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 120
Age >= 18 years of age of either gender
-Admission to trauma ICU within 72 hours of head injury
-GCS >= 5
•Patient with blunt trauma abdomen.
•Severe thoracic injury with associated hemothorax.
•Allergy to macrolide or metoclopramide.
•Patient taking erythromycin or metoclopramide or drugs that interact with them such as carbamazepinem digoxin, cyclosporein, fluconazole etc.
•Malabsorptive gastrointestinal diseases (obstruction, perforation, short bowel syndrome, or Crohnâ??s disease)
•Abnormal liver function (defined by the presence of 2 of the following: transaminases -3 times the upper limit of normal or total bilirubin -3 times the upper limit of normal, or prothrombin time -2 times the upper limit of normal).
•Renal dysfunction requiring active renal replacement therapy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome of the study will be the incidence of high GAV with the use of prokinetic drugsTimepoint: every 4 hrly for 5 days
- Secondary Outcome Measures
Name Time Method Any episode of diarrhea or abdominal distensionTimepoint: every 4 hrly for 5 days;daily gastric volume emptiedTimepoint: daily for 5 days;Enteral Feeding failureTimepoint: every 4 hrly for 5 days;percentage of target calorie requirement metTimepoint: daily for 5 days