Multimodal Analysis of the Young Brain on Rhythm Perception: From Premature Neonates to Infants

Not Applicable

Recruiting

• Conditions: Premature Neonates; fNIRS; ERP; Time Perception; Rhythm; EEG; Discrimination
• Interventions: Other: EEG; Other: NIRS

• Registration Number: NCT05417542
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

Premature neonates are able to discriminate phonemes and voice from 28wGA at a time the neuronal network establish contact between the environment and the cortical neurones. In the present monocentric study the investigators will analyse the response of the cortical network in premature aged between 28 and 40 wGA in response to auditory stimuli using High Resolution Electroencephalography and High Density Near Infrared Spectroscopy

Detailed Description

Not available

Study Timeline

• Status Verified: 2022-05
• Study Start: 2022-05-31
• Study First Submitted: 2022-05-31
• Study First Submitted QC: 2022-06-09
• Last Update Submitted: 2022-06-09
• Study First Posted: 2022-06-14
• Last Update Posted: 2022-06-14
• Primary Completion: 2029-05
• Study Completion: 2029-05

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Full term neonates between 28 and 40 weeks Gestational Age

Exclusion Criteria

• Neonates outside the age range

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control I	NIRS	preterm neonates between 28 and 30 wGA
Control II	EEG	preterm neonates between 32 and 34 wGA
Control II	NIRS	preterm neonates between 32 and 34 wGA
Exposition I	NIRS	preterm neonates between 28 and 30 wGA Exposition to music during the NICU period
Exposition II	NIRS	preterm neonates between 32 and 34 wGA Exposition to music during the NICU period
Control I	EEG	preterm neonates between 28 and 30 wGA
Control III	NIRS	preterm neonates between 36 and 40 wGA
Exposition I	EEG	preterm neonates between 28 and 30 wGA Exposition to music during the NICU period
Exposition II	EEG	preterm neonates between 32 and 34 wGA Exposition to music during the NICU period
Control III	EEG	preterm neonates between 36 and 40 wGA

Primary Outcome Measures

Name	Time	Method
variations of the response of the cortical network using High Density Near Infrared Spectroscopy during auditory stimuli between the 5 infant groups	one day
Variations of the response of the cortical network using High Resolution Electroencephalography before auditory stimuli between the 5 infant groups	one day
variations of the response of the cortical network using High Density Near Infrared Spectroscopy after auditory stimuli between the 5 infant groups	one day
Variations of the response of the cortical network using High Resolution Electroencephalography during auditory stimuli between the 5 infant groups	one day
Variations of the response of the cortical network using High Resolution Electroencephalography after auditory stimuli between the 5 infant groups	one day
variations of the response of the cortical network using High Density Near Infrared Spectroscopy before auditory stimuli between the 5 infant groups	one day

Trial Locations

Locations (1)

CHU Amiens; 🇫🇷 Amiens, France