Single centre, proof-of-concept, exploratory, parallel, controlled study using high-throughput DNA sequencing techniques to compare differences in the gastrointestinal (GI) microflora of Clostridium difficile infection (CDI) and ulcerative colitis (UC) patients before and after faecal microbiota transplantation (FMT)

Centre for Digestive Diseases0 个研究点目标入组 5 人开始时间: 2014年5月12日最近更新: 2020年1月13日

适应症

试验速览

暂无简介。

•6 months or greater history of active moderate ulcerative colitis (Mayo score of 4-10) or diarrhoea (greater than 3 motions per day) in association with a confirmed diagnosis of Clostridium difficile infection (toxin positive).
•Never had FMT treatment for any reason.

•Females who are pregnant or lactating.
•Unwilling to practice an effective method of contraception throughout the study period.
•Unwilling to use a sodium picosulfate-based bowel preparation.
•Severe anemia, leucopenia or granulocytopenia.
•Detection of a gastrointestinal pathogen on stool analysis, with the exception of Clostridium difficile for the Clostridium difficile infection group only.
•Participants with Crohn’s disease, indeterminate colitis or isolated proctitis <5 cm.
•Constipation-predominant ulcerative colitis with <2 bowel motions/day.
•Evidence or history of toxic megacolon.
•Any other significant gastrointestinal conditions e.g. neoplasms, irritable bowel syndrome.
•Participants who have had a colectomy, bowel resection or other major gastrointestinal surgery.

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