Differences in gut bacteria of patients with Clostridium difficile infection and patients with ulcerative colitis before and after faecal microbiota transplantatio

Not Applicable

Completed

• Conditions: Clostridium difficile infection; Ulcerative colitis; Oral and Gastrointestinal - Inflammatory bowel disease; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon; Infection - Other infectious diseases

• Registration Number: ACTRN12614000503628
• Lead Sponsor: Centre for Digestive Diseases

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-05-12
• Study Completion: 2018-08-17
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 5

Inclusion Criteria

6 months or greater history of active moderate ulcerative colitis (Mayo score of 4-10) or diarrhoea (greater than 3 motions per day) in association with a confirmed diagnosis of Clostridium difficile infection (toxin positive).
Never had FMT treatment for any reason.

Exclusion Criteria

Females who are pregnant or lactating.
Unwilling to practice an effective method of contraception throughout the study period.
Unwilling to use a sodium picosulfate-based bowel preparation.
Severe anemia, leucopenia or granulocytopenia.
Detection of a gastrointestinal pathogen on stool analysis, with the exception of Clostridium difficile for the Clostridium difficile infection group only.
Participants with Crohn’s disease, indeterminate colitis or isolated proctitis <5 cm.
Constipation-predominant ulcerative colitis with <2 bowel motions/day.
Evidence or history of toxic megacolon.
Any other significant gastrointestinal conditions e.g. neoplasms, irritable bowel syndrome.
Participants who have had a colectomy, bowel resection or other major gastrointestinal surgery.

Study & Design

• Study Type: Interventional
• Study Design: Not specified