Effects of 12 Weeks of Omega 3 Supplementation on Resting Metabolic Rate
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- Change in Resting Metabolic Rate From Baseline
研究概览
简要总结
Fatty acids are the main components of the cell membranes. It has been demonstrated that diet can alter the characteristics and function of many membranes in the body, which has an effect on cardiovascular and metabolic health. Over the last two decades there has been a substantial rise in the research of the effects of Omega 3 polyunsaturated fatty acids on bodily function. There are two fatty acids that are of particular interest to researchers, eicosapentanoic acid (EPA) and docosahexanoic acid (DHA). These fatty acids have unique unsaturated structures, and their incorporation into biological membranes seems to generate important and positive physiological effects. The body is unable to synthesize these fatty acids in high concentrations to elicit significant effects, so they must be obtained through diet in food or via supplementation.
It has been suggested that EPA and DHA supplementation increases resting metabolic rate (RMR) in humans, in part by increasing the use of fat as a fuel during rest. There are a limited number of studies examining the effects of Omega 3 supplementation on RMR. Some have found an increase in RMR while others have found no change. These studies have some limitations, as that they have either used a small sample size, a low omega fatty acid dose and/or short supplementation periods. Due to the variable results, the investigators will improve the reliability of the RMR measurements by making measures on each subject during two consecutive days at each time point that it is measured (0, 6 and 12 weeks).
Therefore, the purpose of this study is to determine the effects of 12 weeks of omega 3 supplementation (3 g/d) on healthy young adults vs. the supplementation of a placebo. The researchers hypothesize that EPA and DHA supplementation will result in an increase in RMR and fat oxidation in some subjects and not in others. The duplicate RMR measures will determine the prevalence and magnitude of the omega 3 supplementation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •18 - 30 years of age.
- •Must currently practice a consistent diet and exercise regimen, and maintain this throughout the duration of the study.
排除标准
- •Current or previous supplementation with omega-3's.
- •Average fish intake greater than two times per week.
- •Taken any medications, have any medical condition, and hospitalization or surgeries.
- •Allergy to fish/fish oil, , (rosemary extract, ascorbyl palmitate, or natural tocopherols).
结局指标
主要结局
Change in Resting Metabolic Rate From Baseline
时间窗: Baseline, 6 weeks, 12 weeks
Percent change in resting metabolic rate
次要结局
- Change in Whole Body Resting Carbohydrate Oxidation From Baseline(Baseline, 6 weeks, 12 weeks)
- Change in Maximum Oxygen Consumption From Baseline(Baseline, 12 weeks)
- Variability of Resting Metabolic Rate Measurement on 2 Consecutive Days(Baseline, 6 weeks, 12 weeks)
- Change in Whole Body Resting Fat Oxidation From Baseline(Baseline, 6 weeks, 12 weeks)
- Change in Fasted Blood Triglyceride Concentration From Baseline(Baseline, 12 weeks)
研究者
Lawrence Spriet
Professor and Chair
University of Guelph