Sleep Disordered Breathing and Impaired Glucose Homeostasis in Obese Children
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Investigate the prevalence and severity of SDB among children with T2DM compared to its prevalence in non-diabetic obese children.
研究概览
简要总结
SDB has been identified as an important risk factor for insulin resistance and the metabolic syndrome.
In a recent study in patients with SDB and T2DM it was shown that CPAP therapy can lead to improvements in postprandial glucose levels and in glycosylated hemoglobin levels (HbA1c).
In children, there are only 3 studies that have examined the relations between SDB, obesity and the metabolic syndrome.
In order to further understand the relative contribution of SDB to the development of impaired glucose homeostasis and metabolic abnormalities we aim to investigate the prevalence and severity of SDB in children with T2DM compared to obese children without T2DM. The investigators hypothesize that SDB will be more prevalent and more severe among obese children with T2DM compared with the general obese pediatric population.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Years 至 20 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •diagnosed with T2DM
排除标准
- 未提供
结局指标
主要结局
Investigate the prevalence and severity of SDB among children with T2DM compared to its prevalence in non-diabetic obese children.
时间窗: In 6 months
To examine changes in metabolic measures and markers of inflammation and oxidative stress in response to treatment for SDB (adenotonsillectomy) in children with T2DM compared to obese children without T2DM.
时间窗: In 6 months
To measure markers of inflammation and oxidative stress known to be associated with cardiovascular morbidity in children with T2DM and SDB compared to non-diabetic obese children.
时间窗: In 6 months
次要结局
未报告次要终点