Effect of Low-Load Blood Flow Restriction Training for Subjects with Knee Osteoarthritis
Phase 2
- Conditions
- Knee osteoarthritisOsteoarthritis
- Registration Number
- TCTR20210927002
- Lead Sponsor
- Individual
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Meet 3 of the following
1. 50-85 years of age
2. Less than 30 minutes of morning stiffness on knee joint
3. Knee joint crepitus on active motion
4. Bony tenderness around knee joint
5. Bony enlargement around knee joint
6. No palpable warmth of synovium in knee joint
Exclusion Criteria
1. Knee pain intensity less than 1 or greater than 8 (total 10 points)
2. Knee flexion range of motion less than 120 degree
3. Hip flexion range of motion less than 90 degree
4. History of trauma in past 3 months
5. Walk with assistive device
6. Resting systolic blood pressure lower than 100 mmHg or higher than 160 mmHg
7. Resting diastolic blood pressure higher than 100 mmHg
8. Peripheral vascular disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain intensity every 4 weeks until end of the intervention Numerical Rating Scale
- Secondary Outcome Measures
Name Time Method Isometric muscle strength (knee extension, knee flexion, hip extension, hip abduction) every 4 weeks until end of the intervention Hand-held dynamometer,Functional performance every 4 weeks until end of the intervention 30 second chair stand test, 4*10m fast-paced walk test, 20 seconds stair climbing test ,Disability every 4 weeks until end of the intervention Knee injury and Osteoarthritis Outcome Score (Chinese version),Rectus femoris muscle thickness every 4 weeks until end of the intervention Rehabilitative ultrasound imaging ,Self-report outcome measure of function every 4 weeks until end of the intervention Patient Specific Functional Scale,Maximal dynamic strength every 4 weeks until end of the intervention Submaximal predicted 1-RM with dumbbel,Rectus femoris msucle echo intensity every 4 weeks until end of the intervention Rehabilitative ultrasound imaging