Research on the Application of Brain Network Functional Connectivity Analysis Based on Functional Magnetic Resonance Imaging in Proprioceptive Training for Chronic Non-Specific Low Back Pain
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 主要终点
- VAS
研究概览
简要总结
Through longitudinal analysis of dynamic changes in DMN functional connectivity before and after sensory training intervention, combined with pain behavioral and functional improvement indicators, this study systematically reveals the central neural remodeling patterns in CNLBP and establishes an objective efficacy evaluation system based on multimodal imaging.
详细描述
This phase of the research aims to elucidate the neuroplasticity mechanisms induced by CNLBP treatment, providing a theoretical basis for the future development of personalized rehabilitation protocols based on brain network subtypes, ultimately achieving the clinical goals of reducing pain recurrence rates and improving long-term prognosis in patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age between 18 and 60 years old;
- •Current or past low back pain lasting more than three months; ③ No abnormal sensation or reflex abnormalities in the lower limbs; ④ Able to commit to participating in training three times per week for three months.
排除标准
- •Fractures, dislocations, structural abnormalities, prior surgery, metal implants, or lumbar disc herniation;
- •Comorbidities such as severe cardiovascular diseases, neurological disorders, osteoporosis, or metabolic diseases; ③ Low back pain caused by visceral diseases;
- •VAS score (range 1-10) exceeding 8 points;
- •Pregnant or lactating women; ⑥ Symptoms of nerve root irritation; ⑦ Recent participation in core stability training.
结局指标
主要结局
VAS
时间窗: After 4 weeks of treatment
The Visual Analogue Scale (VAS) was used to assess the severity of low back pain, with 0 indicating no pain and 10 indicating unbearable severe pain.
JOA
时间窗: After 4 weeks of treatment
The Japanese Orthopaedic Association (JOA) efficacy assessment criteria for low back disorders were applied to evaluate lumbar function.
次要结局
- MRI(After 4 weeks of treatment)