The Impact of Continuous Versus Intermittent Feeding on Changes in Insulin Sensitivity During Bed-rest
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Change in insulin sensitivity (measured as glucose infusion rate during hyperinsulinaemic-euglycaemic clamp)
Study Overview
Brief Summary
In the present study, the investigators will assess the impact of two different feeding patterns (continuous vs intermittent) on insulin sensitivity and muscle mass following bedrest.
Detailed Description
In the present study, the investigators will assess the impact of two different feeding patterns on insulin sensitivity and muscle mass following bedrest. Healthy, young males will be fed in a continuous (no breaks in food supply) or intermittent (in boluses throughout the day) manner.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 35 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •BMI between 18.5 and 35
- •Recreationally active
Exclusion Criteria
- •Type 2 diabetes
- •Performing progressive resistance training in 6 months prior to study
- •Back/knee/leg problems
- •Hypertension
- •Use of certain anticoagulants
- •All co morbidities interacting with mobility and muscle metabolism of the lower limbs
- •Blood donation in past 3 months
Arms & Interventions
Intermittent feeding
Intermittent feeding pattern throughout the bedrest period, with 4 boluses per day
Intervention: Intermittent feeding pattern (Other)
Continuous feeding
Continuous feeding pattern throughout the bedrest period, with 4 boluses per day, without breaks in food supply.
Intervention: Continuous feeding pattern (Other)
Outcomes
Primary Outcomes
Change in insulin sensitivity (measured as glucose infusion rate during hyperinsulinaemic-euglycaemic clamp)
Time Frame: 7 days bedrest
Secondary Outcomes
- Change in muscle mass (measured as upper leg muscle cross-sectional area with CT scan)(7 days bedrest)
- Change in lean tissue (measured via DEXA scan)(7 days bedrest)