The Impact of Continuous Versus Intermittent Feeding on Changes in Insulin Sensitivity During Bed-rest

Maastricht University Medical Center1 site in 1 country20 target enrollmentOctober 2015

ConditionsAtrophy, Disuse Insulin Resistance

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Atrophy, Disuse
Sponsor: Maastricht University Medical Center
Enrollment: 20
Locations: 1
Primary Endpoint: Change in insulin sensitivity (measured as glucose infusion rate during hyperinsulinaemic-euglycaemic clamp)
Status: Completed
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

In the present study, the investigators will assess the impact of two different feeding patterns (continuous vs intermittent) on insulin sensitivity and muscle mass following bedrest.

Detailed Description

In the present study, the investigators will assess the impact of two different feeding patterns on insulin sensitivity and muscle mass following bedrest. Healthy, young males will be fed in a continuous (no breaks in food supply) or intermittent (in boluses throughout the day) manner.

Registry

clinicaltrials.gov

Start Date

October 2015

End Date

April 2016

Last Updated

9 years ago

Study Type

Interventional

Study Design

Parallel

Sex

Male

Investigators

Sponsor

Maastricht University Medical Center

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•BMI between 18.5 and 35
•Recreationally active

Exclusion Criteria

•Type 2 diabetes
•Performing progressive resistance training in 6 months prior to study
•Back/knee/leg problems
•Hypertension
•Use of certain anticoagulants
•All co morbidities interacting with mobility and muscle metabolism of the lower limbs
•Blood donation in past 3 months

Outcomes

Primary Outcomes

Change in insulin sensitivity (measured as glucose infusion rate during hyperinsulinaemic-euglycaemic clamp)

Time Frame: 7 days bedrest

Secondary Outcomes

Change in muscle mass (measured as upper leg muscle cross-sectional area with CT scan)(7 days bedrest)
Change in lean tissue (measured via DEXA scan)(7 days bedrest)