Bedrest, Feeding Pattern, and Insulin Sensitivity
Not Applicable
Completed
- Conditions
- Insulin ResistanceAtrophy, Disuse
- Registration Number
- NCT02521025
- Lead Sponsor
- Maastricht University Medical Center
- Brief Summary
In the present study, the investigators will assess the impact of two different feeding patterns (continuous vs intermittent) on insulin sensitivity and muscle mass following bedrest.
- Detailed Description
In the present study, the investigators will assess the impact of two different feeding patterns on insulin sensitivity and muscle mass following bedrest. Healthy, young males will be fed in a continuous (no breaks in food supply) or intermittent (in boluses throughout the day) manner.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 20
Inclusion Criteria
- BMI between 18.5 and 35
- Recreationally active
Exclusion Criteria
- Type 2 diabetes
- Performing progressive resistance training in 6 months prior to study
- Back/knee/leg problems
- Hypertension
- Use of certain anticoagulants
- All co morbidities interacting with mobility and muscle metabolism of the lower limbs
- Blood donation in past 3 months
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Change in insulin sensitivity (measured as glucose infusion rate during hyperinsulinaemic-euglycaemic clamp) 7 days bedrest
- Secondary Outcome Measures
Name Time Method Change in muscle mass (measured as upper leg muscle cross-sectional area with CT scan) 7 days bedrest Via single-slice CT scan
Change in lean tissue (measured via DEXA scan) 7 days bedrest Via DEXA
Trial Locations
- Locations (1)
Maastricht University Medical Center+
🇳🇱Maastricht, Limburg, Netherlands
Maastricht University Medical Center+🇳🇱Maastricht, Limburg, Netherlands