Bedrest, Feeding Pattern, and Insulin Sensitivity

Not Applicable

Completed

• Conditions: Insulin Resistance; Atrophy, Disuse
• Interventions: Other: Intermittent feeding pattern; Other: Continuous feeding pattern

• Registration Number: NCT02521025
• Lead Sponsor: Maastricht University Medical Center

Brief Summary

In the present study, the investigators will assess the impact of two different feeding patterns (continuous vs intermittent) on insulin sensitivity and muscle mass following bedrest.

Detailed Description

In the present study, the investigators will assess the impact of two different feeding patterns on insulin sensitivity and muscle mass following bedrest. Healthy, young males will be fed in a continuous (no breaks in food supply) or intermittent (in boluses throughout the day) manner.

Study Timeline

• Study First Submitted: 2015-08-03
• Study First Submitted QC: 2015-08-07
• Study First Posted: 2015-08-13
• Study Start: 2015-10
• Primary Completion: 2016-04
• Study Completion: 2016-04
• Status Verified: 2016-07
• Last Update Submitted: 2016-07-26
• Last Update Posted: 2016-07-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

• BMI between 18.5 and 35
• Recreationally active

Exclusion Criteria

• Type 2 diabetes
• Performing progressive resistance training in 6 months prior to study
• Back/knee/leg problems
• Hypertension
• Use of certain anticoagulants
• All co morbidities interacting with mobility and muscle metabolism of the lower limbs
• Blood donation in past 3 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Intermittent feeding	Intermittent feeding pattern	Intermittent feeding pattern throughout the bedrest period, with 4 boluses per day
Continuous feeding	Continuous feeding pattern	Continuous feeding pattern throughout the bedrest period, with 4 boluses per day, without breaks in food supply.

Primary Outcome Measures

Name	Time	Method
Change in insulin sensitivity (measured as glucose infusion rate during hyperinsulinaemic-euglycaemic clamp)	7 days bedrest

Secondary Outcome Measures

Name	Time	Method
Change in muscle mass (measured as upper leg muscle cross-sectional area with CT scan)	7 days bedrest	Via single-slice CT scan
Change in lean tissue (measured via DEXA scan)	7 days bedrest	Via DEXA

Trial Locations

Locations (1)

Maastricht University Medical Center+; 🇳🇱 Maastricht, Limburg, Netherlands