Fatty Liver and Ectopic Fat in Overweight and Obese Patients
Not Applicable
Completed
- Conditions
- Steatohepatitis
- Interventions
- Procedure: liver biopsy
- Registration Number
- NCT00886301
- Lead Sponsor
- Centre Hospitalier Universitaire de Nice
- Brief Summary
The aim of the study is to find new clinico-biological and medical imaging parameters associated with non alcoholic steatohepatitis in overweight and obese patients.
- Detailed Description
Non invasive assessment of liver fibrosis and liver inflammation and steatosis is clinically relevant in patients exposed to non alcoholic fatty liver diseases.
The aim of the study is to find new clinico-biological and medical imaging parameters associated with non alcoholic steatohepatitis in overweight and obese patients.
Fatty liver and ectopic fat accumulation will be particularly assessed.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 56
Inclusion Criteria
- BMI between 25 and 40
- ALAT level superior to normal level even after 3 months of diet
- alcohol consumption < 20 g/j for women and < 30 g/j for men
Exclusion Criteria
- HIV, hepatitis B virus, hepatitis C virus positive
- known hemochromatosis
- glycemia > 1.26 g/L or under anti-diabetic treatment
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 1 liver biopsy obese or overweight patients with fatty liver or ectopic fat
- Primary Outcome Measures
Name Time Method Liver status will be will be determined by liver biopsy, non invasive liver assessment. Biological and medical imaging parameters will be use to characterize our patients. at inclusion and at year 1
- Secondary Outcome Measures
Name Time Method Non invasive liver assessment, biological and medical imaging parameters will be use to characterize our patients. at year 1
Trial Locations
- Locations (1)
Hepatogastroenterology, Hôpital l'Archet, CHU de Nice
🇫🇷Nice, France