Phase 3 Trial of Elacestrant vs. Standard of Care for the Treatment of Patients With ER+/HER2- Advanced Breast Cancer
- Registration Number
- NCT03778931
- Lead Sponsor
- Stemline Therapeutics, Inc.
- Brief Summary
This Phase 3 clinical study compares the efficacy and safety of elacestrant to the standard of care (SoC) options of fulvestrant or an aromatase inhibitor (AI) in women and men with breast cancer whose disease has advanced on at least one endocrine therapy including a CDK4/6 inhibitor in combination with fulvestrant or an aromatase inhibitor (AI) .
- Detailed Description
This is an international, multicenter, randomized, open-label, active-controlled, event-driven, Phase 3 clinical study comparing the efficacy and safety of elacestrant to the SoC options of fulvestrant or an aromatase inhibitor (AI) in postmenopausal women and in men with advanced or metastatic ER+/HER2- breast cancer, either in subjects with tumors that harbor mutations in the ligand binding domain (LBD) of the estrogen receptor 1 (ESR1) gene (ESR1-mut subjects) or in all subjects regardless of ESR1 status (ESR1-mut and ESR1 wild type \[ESR1-WT\]) and whose disease has relapsed or progressed on at least one and no more than two prior lines of endocrine therapy (with documented progression), which must have included prior CDK4/6 inhibitor therapy in combination with fulvestrant or an aromatase inhibitor (AI) and for whom hormonal monotherapy with one of the SoC drugs (fulvestrant, anastrozole, letrozole, exemestane) is an appropriate treatment option.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 478
- Subjects with proven diagnosis of adenocarcinoma of the breast with evidence of either locally advanced disease not amenable to resection or radiation therapy with curative intent or metastatic disease not amenable to curative therapy.
- Subjects must be appropriate candidates for endocrine monotherapy
- Subjects must have measurable disease or bone only disease
- Female or male subjects age ≥ 18 years; female subjects must be postmenopausal women and male subjects must not allow pregnancy with their sperm (abstain, do not donate sperm, etc).
- Subjects must have ER+ and HER2- tumor status
- Subjects must have previously received at least one and no more than two lines of endocrine therapy for advanced/metastatic breast cancer and meet additional previous treatment criteria.
- Subjects must have received prior treatment with a CDK4/6 inhibitor in combination with either fulvestrant or an aromatase inhibitor (AI) for advanced/metastatic breast cancer (mBC).
- Subjects may have received no more than one line of chemotherapy in the advanced/metastatic setting.
Critical
-
Prior treatment with elacestrant or other investigational selective estrogen receptor degrader (SERD) or ER antagonist (D-0502, GDC-0810, GDC- 0927, GDC-9545, G1T-48, LSZ102, AZD9496, SAR439859, ZN-c5, H3B-6545, bazedoxifene, lasofoxifene).
-
Prior anticancer or investigational drug treatment within the following windows:
- Fulvestrant treatment < 42 days before first dose of study drug
- Any endocrine therapy < 14 days before first dose of study drug
- Chemotherapy < 21 days before first dose of study drug
- Any investigational anti-cancer drug therapy < 28 days or five half-lives (whichever is shorter) before the first dose of study drug. Enrollment of subjects whose most recent therapy was an investigational agent should be discussed with the Sponsor
- Bisphosphonates or RANKL inhibitors initiated or dose changed < 3 months prior to first dose of study drug
-
Presence of symptomatic visceral disease as defined in protocol.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Elacestrant Elacestrant Subjects in Arm 1 will receive elacestrant Standard of Care (SoC) Standard of Care Subjects in Arm 2 will receive Investigator's choice of one of the Standard of Care drugs (fulvestrant, anastrozole, letrozole, or exemestane)
- Primary Outcome Measures
Name Time Method Progression-free Survival in ESR1-mut Subjects From Date of Randomization until Disease Progression or Death Due to Any Cause (up to 12 Months) Progression-free Survival based on blinded IRC assessment in ESR1-mut subjects defined as the length of time from randomization until the date of objective disease progression per Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1) as assessed by the blinded IRC or death from any cause. Progression is defined per RECIST v1.1 as a 20% increase in the sum of the longest diameter of target lesions, or a measurable increase in a non-target lesion, or the appearance of new lesions.
Progression-free Survival in All Subjects From Date of Randomization until Disease Progression or Death Due to Any Cause (up to 12 Months) Progression-free Survival based on blinded Imaging Review Committee (IRC) assessment in all (ESR1-mut and ESR1-WT) subjects
- Secondary Outcome Measures
Name Time Method Overall Survival in ESR1-mut Subjects From Date of Randomization until Death Due to Any Cause (Estimated up to 24 Months) Overall Survival in ESR1-mut subjects, where Overall Survival is defined as the length of time from randomization until the date of death from any cause
Overall Survival in All Subjects From Date of Randomization until Death Due to Any Cause (Estimated up to 24 Months) Overall Survival in All (ESR1-mut and ESR1-WT) Subjects
Trial Locations
- Locations (244)
Dayton Oncology & Hematology
🇺🇸Kettering, Ohio, United States
Keck Medical Center of USC
🇺🇸Los Angeles, California, United States
UCLA Hematology/Oncology
🇺🇸Los Angeles, California, United States
Chicago Association for Research and Education in Science
🇺🇸Chicago, Illinois, United States
Rush University Cancer Center
🇺🇸Chicago, Illinois, United States
University Hospitals of Cleveland
🇺🇸Cleveland, Ohio, United States
Benaroya Research Institute at Virginia Mason
🇺🇸Seattle, Washington, United States
Massachusetts General Hospital Cancer Center
🇺🇸Boston, Massachusetts, United States
Mass General Cancer Center at Newton Wellesley - Oncology
🇺🇸Boston, Massachusetts, United States
Bioclinic Thessaloniki
🇬🇷Thessaloniki, Greece
Minnesota Oncology
🇺🇸Minneapolis, Minnesota, United States
US Oncology Network
🇺🇸Cincinnati, Ohio, United States
Texas Oncology - Willowbrook
🇺🇸Houston, Texas, United States
Cancer Therapy and Research Center at UTHSCSA
🇺🇸San Antonio, Texas, United States
Boston Medical Center
🇺🇸Boston, Massachusetts, United States
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Utah Cancer Specialists
🇺🇸Salt Lake City, Utah, United States
UCSF Medical Center
🇺🇸San Francisco, California, United States
Oncology and Haematology Clinic - Michael Garron Hospital
🇨🇦East York, Ontario, Canada
Institut régional du Cancer Montpellier Service pharmacie-Essais cliniques
🇫🇷Montpellier, France
Centre Georges Francois Leclerc
🇫🇷Dijon, France
St Bernard's Cancer Care
🇺🇸Jonesboro, Arkansas, United States
The University of Arizona Cancer Center
🇺🇸Tucson, Arizona, United States
USC IDS Pharmacy
🇺🇸Los Angeles, California, United States
UCLA West Medical Pharmacy 159
🇺🇸Los Angeles, California, United States
TMPN Cancer Care
🇺🇸Redondo Beach, California, United States
UCHealth Cancer Center
🇺🇸Fort Collins, Colorado, United States
Highland Clinic
🇺🇸Shreveport, Louisiana, United States
New England Cancer Specialists
🇺🇸Scarborough, Maine, United States
Precision Cancer Research
🇺🇸Freehold, New Jersey, United States
Stony Brook University
🇺🇸Stony Brook, New York, United States
Toledo Clinic Cancer Center
🇺🇸Toledo, Ohio, United States
Abington Hematology Oncology Associates
🇺🇸Willow Grove, Pennsylvania, United States
Austin Cancer Centers
🇺🇸Austin, Texas, United States
Texas Oncology-Presbyterian Cancer Center Dallas
🇺🇸Dallas, Texas, United States
Elligo Health Research
🇺🇸Austin, Texas, United States
Texas Oncology-Beaumont
🇺🇸Beaumont, Texas, United States
Texas Oncology-Methodist Dallas Cancer Center
🇺🇸Dallas, Texas, United States
University of Virginia Cancer Center
🇺🇸Charlottesville, Virginia, United States
Inova Schar Cancer Institute
🇺🇸Fairfax, Virginia, United States
Clínica Pergamino S.A.
🇦🇷Pergamino, Buenos Aires, Argentina
Clínica Universitaria Reina Fabiola
🇦🇷Córdoba, Argentina
Oncología en Ciudad Autónoma de Buenos Aires
🇦🇷Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina
Mater Misericordiae Ltd Mater Cancer Care Centre
🇦🇺Brisbane, Queensland, Australia
Fundación CORI
🇦🇷La Rioja, Argentina
Sunshine Coast University Hospital
🇦🇺Birtinya, Australia
Macarthur Cancer Therapy
🇦🇺Campbelltown, Australia
Klinikum Wels-Grieskirchen GmbH
🇦🇹Wels, Oberösterreich, Austria
Landeskrankenhaus (LKH) Leoben-Eisenerz
🇦🇹Leoben, Steiermark, Austria
AZ Klina
🇧🇪Brasschaat, Antwerpen, Belgium
Department für Hämato-Onkologie - LKH Hochsteiermark
🇦🇹Leoben, Steiermark, Austria
UZ Antwerpen - Oncologie
🇧🇪Edegem, Antwerpen, Belgium
UZ Brussel - Campus Jette
🇧🇪Brussel, Brussels Capital Region, Belgium
Centre Hospitalier de l'Ardenne - Site de Libramont
🇧🇪Libramont, Luxembourg, Belgium
Onze-Lieve-Vrouwziekenhuis Aalst
🇧🇪Aalst, Oost-Vlaanderen, Belgium
Universitaire Ziekenhuizen (UZ) - Leuven Cancer Institute
🇧🇪Leuven, Vlaams Brabant, Belgium
AZ Groeninge - Campus Kennedylaan
🇧🇪Kortrijk, Belgium
CHU UCL Namur - Site Sainte-Elisabeth
🇧🇪Namur, Belgium
CHU UCL Namur Campus Sainte-Elisabeth
🇧🇪Namur, Belgium
Pharmacie du CRCHUM
🇨🇦Montreal, Quebec, Canada
Clinique Saint Pierre
🇧🇪Ottignies, Belgium
Odense Universitetshospital - Oncology
🇩🇰Odense, Denmark
McGill University Health Centre - Cedars Cancer Center - Oncology
🇨🇦Montreal, Quebec, Canada
Strasbourg Oncologie Libérale Centre de Radiothérapie
🇫🇷Strasbourg, Bas-Rhin, France
Næstved Sygehus
🇩🇰Næstved, Zeeland, Denmark
Aalborg Universitetshospital
🇩🇰Aalborg, Denmark
Vejle Sygehus
🇩🇰Vejle, South Denmark, Denmark
Centre de Lutte Contre le Cancer (CLCC)
🇫🇷Caen, Calvados, France
Onkologisk Afdeling, Lillebælt Hospital, Vejle
🇩🇰Næstved, Zeeland, Denmark
CHU de Quebec - Hopital du Saint Sacrement
🇨🇦Québec, Canada
Hôpital Privé Jean Mermoz Département Pharmacie
🇫🇷Lyon, Rhône, France
Pécsi Tudományegyetem Klinikai Központ
🇭🇺Pécs, Baranya, Hungary
Metropolitan Hospital - Oncology Unit
🇬🇷Athens, Attiki, Greece
University General Hospital Of Patras - Dpt Of Medicine, Division Oncology
🇬🇷Patra, Achaïa, Greece
University General Hospital of Larissa
🇬🇷Larissa, Larisa, Greece
Bács-Kiskun Megyei Kórház
🇭🇺Debrecen, Hajdú-Bihar, Hungary
Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz - Rendeloint
🇭🇺Szolnok, Jász-Nagykun-Szolnok, Hungary
Bon Secours Hospital [Oncology]
🇮🇪Cork City, Cork, Ireland
Semmelweis Egyetem, Onkológiai Központ,
🇭🇺Budapest, Hungary
Országos Onkológiai Intézet
🇭🇺Budapest, Hungary
Pharmacy Aseptic Compounding Unit Level 4, Sligo University Hospital
🇮🇪Sligo, Ireland
The Chaim Sheba Medical Center
🇮🇱Tel-Hashomer, HaMerkaz, Israel
Regional Cancer Center
🇮🇹Meldola, Forli-Cesena, Italy
AOU Maggiore della Carità - SC Oncologia
🇮🇹Novara, Italy
Azienda Ospedaliero-Universitaria di Parma
🇮🇹Parma, Italy
IRCCS Policlinico San Matteo
🇮🇹Pavia, Italy
Via G. Dottore, 1 Sc Oncologia Medica Azienda Ospedaliera di Perugia
🇮🇹Perugia, Italy
SO S.Chiara, AOU Pisana - Oncologia 2
🇮🇹Pisa, Italy
Policlinico Universitario Campus Bio-medico, Università Campus Bio-medico di Roma,
🇮🇹Roma, Italy
Instituto Português de Oncologia de Coimbra
🇵🇹Coimbra, Portugal
Hospital Clínico Universitario de Valencia
🇪🇸Valencia, Spain
Servicio de Oncología Médica Edificio Materno
🇪🇸Madrid, Spain
IOB Ruber Internacional
🇪🇸Madrid, Spain
Hospital Universitario La Paz
🇪🇸Madrid, Spain
Kent Oncology Centre, Maidstone Hospital
🇬🇧Maidstone, Kent, United Kingdom
University College London Hospitals
🇬🇧London, United Kingdom
Sarah Cannon Research Institute
🇬🇧London, United Kingdom
Velindre Cancer Centre - Oncology
🇬🇧Cardiff, United Kingdom
National Cancer Center
🇰🇷Goyang, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
US Oncology - Rocky Mountain Cancer Centers - Midtown
🇺🇸Denver, Colorado, United States
Karmanos Cancer Institute
🇺🇸Detroit, Michigan, United States
Oregon Health and Science University
🇺🇸Portland, Oregon, United States
Colombia St. Mary's Medical Oncology
🇺🇸Milwaukee, Wisconsin, United States
Galilee Medical Center
🇮🇱Nahariya, Israel
Rabin Medical Center - Beilinson Hospital - Davidoff Cancer
🇮🇱Petah Tikva, Israel
Assaf Harofeh Medical Center
🇮🇱Zerifin, Israel
Tel Aviv Sourasky Medical Center - Oncology
🇮🇱Tel-Aviv, Israel
Mayo Clinic
🇺🇸Rochester, Minnesota, United States
Lankenau Medical Center
🇺🇸Wynnewood, Pennsylvania, United States
Healthcare Research Network II
🇺🇸Tinley Park, Illinois, United States
St. Jude Heritage Healthcare
🇺🇸Fullerton, California, United States
Moores Cancer Center at UC San Diego Health
🇺🇸La Jolla, California, United States
Keck Hospital of USC-Norris Healthcare (HC3), Investigational Drug Service (IDS)
🇺🇸Los Angeles, California, United States
Adventist Health Glendale
🇺🇸Glendale, California, United States
Ridley-Tree Cancer Center
🇺🇸Santa Barbara, California, United States
Poudre Valley Health Care, Inc. d/b/a Poudre Valley Health System
🇺🇸Fort Collins, Colorado, United States
MedStar Washington Hospital Center
🇺🇸Washington, District of Columbia, United States
Piedmont Cancer Institute, P.C. - Oncology
🇺🇸Atlanta, Georgia, United States
Suburban Hematology-Oncology Associates
🇺🇸Lawrenceville, Georgia, United States
Northwest Georgia Oncology Centers
🇺🇸Marietta, Georgia, United States
Cancer Care Center of Decatur
🇺🇸Decatur, Illinois, United States
Presence Medical Group Hematology Oncology
🇺🇸Skokie, Illinois, United States
Fort Wayne Medical Oncology And Hematology
🇺🇸Fort Wayne, Indiana, United States
Joliet Oncology-Hematology Associates
🇺🇸Joliet, Illinois, United States
Simmons Cancer Institute
🇺🇸Springfield, Illinois, United States
Goshen Center for Cancer Care
🇺🇸Goshen, Indiana, United States
Hematology Oncology Of Indiana
🇺🇸Indianapolis, Indiana, United States
Cancer Resource Centre
🇺🇸Munster, Indiana, United States
University of Kansas Cancer Center
🇺🇸Westwood, Kansas, United States
Ochsner Medical Center
🇺🇸New Orleans, Louisiana, United States
Pikeville Medical Center - Oncology/Hematology
🇺🇸Pikeville, Kentucky, United States
Weinberg Cancer Institute at Franklin Square
🇺🇸Baltimore, Maryland, United States
The Gynecologic Oncology Center at Mercy
🇺🇸Baltimore, Maryland, United States
Maryland Oncology Hematology
🇺🇸Frederick, Maryland, United States
Mass General North Shore Cancer Center - Oncology
🇺🇸Danvers, Massachusetts, United States
Jackson Oncology Associates, PLLC.
🇺🇸Jackson, Mississippi, United States
Chub O'Reilly Cancer Center
🇺🇸Springfield, Missouri, United States
The Fred & Pamela Buffett Cancer Center
🇺🇸Omaha, Nebraska, United States
Saint Barnabas Medical Center - Cancer Center
🇺🇸Livingston, New Jersey, United States
New Mexico Oncology Hematology Consultants - Oncology
🇺🇸Albuquerque, New Mexico, United States
The Steeplechase Cancer Center
🇺🇸Somerville, New Jersey, United States
New York Oncology Hematology
🇺🇸Albany, New York, United States
New Mexico Cancer Care Alliance
🇺🇸Albuquerque, New Mexico, United States
Northern Westchester Hospital Cancer Center
🇺🇸Mount Kisco, New York, United States
New York University Clinical Cancer Center
🇺🇸New York, New York, United States
Oncology and Hematology of White Plains
🇺🇸White Plains, New York, United States
Carolina Institute For Clinical Research
🇺🇸Fayetteville, North Carolina, United States
Gettysburg Cancer Center
🇺🇸Gettysburg, Pennsylvania, United States
Pinnacle Health Cancer Institute
🇺🇸Harrisburg, Pennsylvania, United States
Brig Center For Cancer Care And Survivorship
🇺🇸Knoxville, Tennessee, United States
Texas Oncology - Central Austin Cancer Center
🇺🇸Austin, Texas, United States
West Cancer Center
🇺🇸Germantown, Tennessee, United States
Texas Oncology-Medical City Dallas
🇺🇸Dallas, Texas, United States
Texas Oncology - McAllen
🇺🇸McAllen, Texas, United States
Texas Oncology-Mesquite
🇺🇸Mesquite, Texas, United States
Texas Oncology-Plano West
🇺🇸Plano, Texas, United States
Texas Oncology-Paris
🇺🇸Paris, Texas, United States
Texas Oncology-Plano East
🇺🇸Plano, Texas, United States
Renovatio Medical The Woodlands
🇺🇸The Woodlands, Texas, United States
Texas Oncology - The Woodlands, Gynecologic Oncology
🇺🇸The Woodlands, Texas, United States
USO Texas Oncology - Tyler
🇺🇸Tyler, Texas, United States
Fort Belvoir Community Hospital
🇺🇸Fort Belvoir, Virginia, United States
University of Wisconsin Carbone Cancer Center
🇺🇸Madison, Wisconsin, United States
Centro Médico Austral
🇦🇷Buenos Aires, Ciudad Autónoma De Buenos Aire, Argentina
Fundacion CENIT para la Investigación en Neurociencias - Clinic
🇦🇷Buenos Aires, Ciudad Autonoma De Buenos Aires, Argentina
St Vincent's Hospital Melbourne
🇦🇺Fitzroy, Victoria, Australia
Oncología Médica
🇦🇷Rosario, Santa Fe, Argentina
Sanatorio del Salvador
🇦🇷Córdoba, Argentina
Institut Jules Bordet - Oncologie Médicale
🇧🇪Brussels, Brussels Capital Region, Belgium
Universitätsklinik Innsbruck
🇦🇹Innsbruck, Tirol, Austria
AZ Turnhout
🇧🇪Turnhout, Antwerpen, Belgium
AZ Nikolaas - Campus Sint-Niklaas Moerland
🇧🇪Sint-Niklaas, Oost-Vlaanderen, Belgium
AZ Sint-Jan Brugge - Oostende AV - Campus Sint-Jan - Oncology
🇧🇪Brugge, West-Vlaanderen, Belgium
AZ Groeninge
🇧🇪Kortrijk, West-Vlaanderen, Belgium
Hopital Trousseau - Service d'Oncologie Medicale
🇫🇷Tours, Indre-et-Loire, France
Centre Oscar Lambret, Department de Cancérologie Sénologique
🇫🇷Lille, Nord, France
Centre Jean Perrin
🇫🇷Clermont Ferrand, Puy-de-Dôme, France
Centre Leon Berard Oncologie Médical
🇫🇷Lyon, Rhône, France
Centre François Baclesse Service Pharmacie
🇫🇷Caen, France
Centre DeLutte Contre Le Cancer - Institut Curie - Departement d'Oncologie Medica
🇫🇷Paris, France
Institut de Cancérologie Lucien Neuwirth Service pharmacie-Essais cliniques
🇫🇷Saint-Priest-en-Jarez, France
Institut Curie Saint-Cloud
🇫🇷Saint-Cloud, Île-de-France, France
Szabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi Oktatókór
🇭🇺Nyiregyhaza, Szabolcs-Szatmár-Bereg, Hungary
Debreceni Egyetem Klinikai Központ
🇭🇺Debrecen, Hajdú-Bihar, Hungary
Uzsoki Utcai Kórház
🇭🇺Budapest, Hungary
Beaumont Hospital Cancer Clinical Trials Unit
🇮🇪Dublin, Ireland
Sligo University Hospital
🇮🇪Sligo, Ireland
Pharmacy, UHW
🇮🇪Waterford, Ireland
Sharett Institute of Oncology - Hadassah Medical Center
🇮🇱Jerusalem, HaMerkaz, Israel
Meir Medical Center
🇮🇱Kfar-Saba, Israel
Hadassah MO - Oncology
🇮🇱Jerusalem, Israel
Policlinico S.Orsola Malpighi, AOU di Bologna - SSD Oncol.Med. Addarii-Zamagni
🇮🇹Bologna, Italy
IRCCS Istituto Clinico Humanitas Humanitas Cancer Center
🇮🇹Rozzano, Milano, Italy
Ospedale San Gerardo-ASST Monza
🇮🇹Monza, Monza E Brianza, Italy
PO di Cremona, ASST di Cremona - Patologia Mammaria e Breast Unit - Cremona
🇮🇹Cremona, Italy
DiMI, Dipartimento di Medicina interna e Specialità mediche,
🇮🇹Genova, Italy
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
🇮🇹Meldola, Italy
Azienda Ospedaliero-Universitaria Policlinico di Modena
🇮🇹Modena, Italy
Gachon University Gil Medical Center
🇰🇷Incheon, Korea, Republic of
Azienda Sanitaria Universitaria Integrata di Udine
🇮🇹Udine, Italy
Policlinico A. Gemelli
🇮🇹Roma, Italy
Seoul National University Hospital
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam-si, Korea, Republic of
Korea University Anam Hospital
🇰🇷Seoul, Korea, Republic of
Hospital Universitario Virgen del Rocio
🇪🇸Sevilla, Andalucía, Spain
Hospital Universitario Son Espases, Servicio de Oncología
🇪🇸Palma de Mallorca, Illes Balears, Spain
Hospital Universitario de Fuenlabrada. Servicio de Oncología
🇪🇸Fuenlabrada, Madrid, Spain
Hospital de Navarra
🇪🇸Pamplona, Navarra, Spain
Hospital Clinic de Barcelona
🇪🇸Barcelona, Spain
M.D Anderson Center Madrid
🇪🇸Madrid, Spain
Hospital Xeral Álvaro Cunqueiro
🇪🇸Vigo, Pontevedra, Spain
Hospital Clínico San Carlos
🇪🇸Madrid, Spain
Hospital Universitario Virgen de la Macarena
🇪🇸Sevilla, Spain
University Hospital Southampton NHS Foundation Trust
🇬🇧Southampton, Hampshire, United Kingdom
UC Davis Medical Center, Investigational Drug Service
🇺🇸Sacramento, California, United States
Anschutz Cancer Center Pavilion
🇺🇸Aurora, Colorado, United States
Yale Cancer Center
🇺🇸New Haven, Connecticut, United States
Orlando Health Cancer Institute
🇺🇸Orlando, Florida, United States
Moffitt Cancer Center
🇺🇸Tampa, Florida, United States
Norton Cancer Institute
🇺🇸Louisville, Kentucky, United States
Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
Hospital da Luz
🇵🇹Lisboa, Portugal
Abteilung für Innere Medizin IV
🇦🇹Wels, Oberösterreich, Austria
Clínica Caipo
🇦🇷San Miguel De Tucumán, Tucumán, Argentina
CHU Brugmann
🇧🇪Bruxelles, Brussels Capital Region, Belgium
Cliniques Universitaires Saint-Luc - Oncology
🇧🇪Bruxelles, Brussels Capital Region, Belgium
Grand Hôpital de Charleroi - Site Notre-Dame
🇧🇪Charleroi, Hainaut, Belgium
Instituto Português de Oncologia do Porto
🇵🇹Porto, Portugal
Instituto Português Oncologia Francisco Gentil do Porto
🇵🇹Porto, Portugal
Taunton and Somerset NHS Trust
🇬🇧Taunton, Somerset, United Kingdom
INDC Entité Jolimontoise - CH de Jolimont-Lobbes
🇧🇪Haine-Saint-Paul, Hainaut, Belgium
Hospital Senhora da Oliveira - Guimarães, E.P.E.
🇵🇹Guimarães, Portugal
Hospital General Universitario de Elche
🇪🇸Elche, Alicante, Spain
IUCT-Oncopole Pharmacie-Essais Cliniques
🇫🇷Toulouse, Haute-Garonne, France
Clinical Research Facility, St. James's Hospital
🇮🇪Dublin, Ireland
St Vincent's University Hospital
🇮🇪Dublin, Ireland
Hospital de Dia de Oncología
🇪🇸La Laguna, Canarias, Spain
Hospital Universitario de Canarias
🇪🇸Tenerife, Canarias, Spain
Mount Vernon Cancer Centre
🇬🇧Northwood, England, United Kingdom
Charleston Oncology
🇺🇸Charleston, South Carolina, United States
MUSC Hollings Cancer Center
🇺🇸Charleston, South Carolina, United States
Montefiore Medical Center
🇺🇸Bronx, New York, United States