Evaluation of the effect of stannous fluoride and Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) -containing oral care products on remineralisation of enamel subsurface lesions in healthy volunteers wearing a palatal appliance with enamel slabs in a double-blind randomised in situ clinical trial

niversity of Melbourne0 sites6 target enrollmentFebruary 17, 2022

Overview

No summary available.

Registry

who.int

Start Date

February 17, 2022

End Date

TBD

Last Updated

4 years ago

Study Type

Interventional

Sex

All

Sponsor

niversity of Melbourne

•Inclusion Criteria
•Age range: 18 to 75 years.
•Gender: Males and females.
•Good general health.
•At least 22 natural teeth
•A gum\- stimulated whole salivary flow rate at least 1\.0 ml/minute and unstimulated whole salivary flow rate at least 0\.2 ml/minute.
•Available for both treatment periods.

•The exclusion criteria include:
•1\) History of adverse or allergic reactions to milk proteins (such as casein), tin or tin\-containing products, or any other ingredients in the
•2\) Orthodontic appliances or removable dentures;
•3\) Veneers, or more than one incisor with an artificial crown;
•4\) Oral diseases including advanced periodontal disease;
•5\) Chronic disease such as diabetes or use of medications that cause gum swelling;
•6\) Untreated decay;
•7\) Treatment with antibiotics or anti\-inflammatory medicines in the month prior to starting the study;
•8\) Use of drugs that may interact with the toothpaste slurries or which may affect salivary flow rate;
•9\) History of health conditions requiring antibiotic coverage prior to dental treatment;