A comparison of the effects of two oral care products on early tooth decay.

Not Applicable

• Conditions: dental caries; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon

• Registration Number: ACTRN12622000306718
• Lead Sponsor: niversity of Melbourne

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-02-17
• Last Update Posted: 28 February 2022

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 6

Inclusion Criteria

Inclusion Criteria
Age range: 18 to 75 years.
Gender: Males and females.
Good general health.
At least 22 natural teeth
A gum- stimulated whole salivary flow rate at least 1.0 ml/minute and unstimulated whole salivary flow rate at least 0.2 ml/minute.
Available for both treatment periods.

Exclusion Criteria

The exclusion criteria include:
1) History of adverse or allergic reactions to milk proteins (such as casein), tin or tin-containing products, or any other ingredients in the
products;
2) Orthodontic appliances or removable dentures;
3) Veneers, or more than one incisor with an artificial crown;
4) Oral diseases including advanced periodontal disease;
5) Chronic disease such as diabetes or use of medications that cause gum swelling;
6) Untreated decay;
7) Treatment with antibiotics or anti-inflammatory medicines in the month prior to starting the study;
8) Use of drugs that may interact with the toothpaste slurries or which may affect salivary flow rate;
9) History of health conditions requiring antibiotic coverage prior to dental treatment;
10) Pregnancy/lactation;
11) Serious infectious disease;
12) Any other medical or dental condition deemed to put the health and wellbeing of you or the research team at risk if you participated in
the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Remineralisation of artificially-created enamel subsurface carious lesions measured by calculating the difference in mineral content of lesions exposed to the paste slurries, using microdensitometric analysis of microradiographic images of the lesions.[14 days post-intervention commencement.<br><br>]

Secondary Outcome Measures

Name	Time	Method
Remineralisation of dentine subsurface carious lesions assessed using microdensitometric analysis of microradiographic images of the lesions.<br><br>[14 days post-intervention commencement.];Occlusion of the microscopic tubules in dentine assessed using a scanning electron microscope.[14 days post-intervention commencement.]