Relationship Between Endoplasmic Reticulum Stress and Pain in Patients With Endometriosis

Completed

• Conditions: Endoplasmic Reticulum Stress; Endometriosis-related Pain; Endometriosis

• Registration Number: NCT04440397
• Lead Sponsor: Kanuni Sultan Suleyman Training and Research Hospital

Brief Summary

The correlation between painful symptoms (dysmenorrhea, dysparonia, dysuria, chronic pelvic pain) symptoms and endoplasmic reticulum stress was investigated in 86 patients diagnosed with endometriosis. For this, xbp-1 (x box binding protein-1) level was measured in patients. XBP-1 is an endoplasmic reticulum stress indicator and is known to be involved in pain pathogenesis.

Detailed Description

Women between the ages of 18-50 who were diagnosed with endometriosis by surgery and ultrasound, without known rheumatological or metabolic diseases were included in the study. Most of the patients are composed of newly diagnosed patients.

Study Timeline

• Study Start: 2020-03-17
• Study First Submitted: 2020-06-17
• Study First Submitted QC: 2020-06-17
• Study First Posted: 2020-06-19
• Status Verified: 2020-08
• Primary Completion: 2020-08-01
• Study Completion: 2020-08-04
• Last Update Submitted: 2020-08-05
• Last Update Posted: 2020-08-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 86

Inclusion Criteria

• diagnosed endometriosis with ultrasound or surgery
• no metabolic diseases
• no rheumatological diseases

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Exclusion Criteria

• Immune modulator, hormonal, anti-inflammatory use history in the last 3 months

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evaluation of the correlations between the results of XBP-1 levels and the stages and pain symptoms of endometriosis.	5 months

Secondary Outcome Measures

Name	Time	Method
serum XBP-1levels in patients wit endometriosis	5 months

Trial Locations

Locations (1)

Pinar Yalcin Bahat; 🇹🇷 Istanbul, İ̇stanbul, Turkey