Endoplasmic Reticulum Stress and Endometriosis Releated Pain
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 86
- 试验地点
- 1
- 主要终点
- Evaluation of the correlations between the results of XBP-1 levels and the stages and pain symptoms of endometriosis.
研究概览
简要总结
The correlation between painful symptoms (dysmenorrhea, dysparonia, dysuria, chronic pelvic pain) symptoms and endoplasmic reticulum stress was investigated in 86 patients diagnosed with endometriosis. For this, xbp-1 (x box binding protein-1) level was measured in patients. XBP-1 is an endoplasmic reticulum stress indicator and is known to be involved in pain pathogenesis.
详细描述
Women between the ages of 18-50 who were diagnosed with endometriosis by surgery and ultrasound, without known rheumatological or metabolic diseases were included in the study. Most of the patients are composed of newly diagnosed patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •diagnosed endometriosis with ultrasound or surgery
- •no metabolic diseases
- •no rheumatological diseases
排除标准
- •Immune modulator, hormonal, anti-inflammatory use history in the last 3 months
结局指标
主要结局
Evaluation of the correlations between the results of XBP-1 levels and the stages and pain symptoms of endometriosis.
时间窗: 5 months
次要结局
- serum XBP-1levels in patients wit endometriosis(5 months)
研究者
Pınar Yalcin bahat
Principal Investigator
Kanuni Sultan Suleyman Training and Research Hospital