Anti-Proteinuric Response to ACEI, ARB and Diuretics Combination.

Phase 4

Terminated

• Conditions: Heavy Proteinuria

• Registration Number: NCT00200694
• Lead Sponsor: Nantes University Hospital

Brief Summary

Determine the best strategy for proteinuria lowering in patients with proteinuria \> 1 g/day receiving ACEI and ARB combination: either increase of ACEI and ARB dosage or increase of diuretic dosage.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-03
• Study First Submitted: 2005-09-13
• Study First Submitted QC: 2005-09-13
• Study First Posted: 2005-09-20
• Primary Completion: 2007-03
• Study Completion: 2007-03
• Status Verified: 2009-02
• Last Update Submitted: 2009-02-03
• Last Update Posted: 2009-02-04

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• proteinuria > 1 g/day with ramipril 5 + valsartan 80 mg/day for 2 months
• proteinuria changes < 50% on 3 separate dosages over 2 months.

Exclusion criteria:

• age < 18 or > 80 years systolic BP < 110 or ≥ 140 mmHg, serum creatinine > 250 mmole/L
• serum creatinine increase on ramipril + valsartan > 20%
• intolerance to ACEI or ARB

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Trial Locations

Locations (1)

CHU de Nantes; 🇫🇷 Nantes, France