Aspiration versus Chest Tube drainage in pleural infectION trial (ACTion)

orth Bristol NHS Trust0 个研究点目标入组 30 人开始时间: 2019年12月5日最近更新: 2022年9月12日

试验速览

2022 Preprint results in https://doi.org/10.21203/rs.3.rs-1552240/v1 (added 10/08/2022) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/36042460/ (added 31/08/2022)

•Patient meeting criteria for pleural infection or complex parapneumonic effusion requiring drainage using international definition (see below):
•1. Purulent pleural fluid
•2. Pleural fluid pH = 7.2
•3. Pleural fluid glucose = 3.4 mmol/L
•4. Pleural fluid gram stain and/or culture positive for bacteria
•5. Large effusion occupying >50% of hemithorax

•1. RAPID score 5 to 7 (higher risk of mortality)
•2. Severe septations/locations on ultrasound (assessed using a validated scoring system)
•3. Ongoing sepsis requiring support beyond basic fluid resuscitation
•4. Uncorrectable coagulopathy
•5. Unable to consent for study
•6. Previous pneumonectomy, recent thoracic surgery or indwelling pleural catheter on side of pleural infection
•7. Age < 18 years
•8. Lives alone with no access to a telephone

发起方

orth Bristol NHS Trust