Acute Effects of Grape and Pomegranate Polyphenols as Modulators of Metabolic Syndrome in Humans
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Postprandial glucose
研究概览
简要总结
The aim of this is study is to evaluate the acute effect of grape and pomegranate polyphenols in the modulation of markers of metabolic syndrome. Most of the previous works about polyphenols have only considered a fraction of polyphenols, i.e., extractable polyphenols. As a consequence, an important amount of dietary polyphenols, the so-called non-extractable polyphenols are ignored. In contrast, the effect of both extractable and non-extractable polyphenols will be considered in this study. Furthermore, the effect of both polyphenols as present in the food matrix and metabolites derived from microbial fermentation will be evaluated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Abdominal perimeter ≥102 cm. for male participants and ≥88 cm for female participants.
- •Subjects presenting some or several of these characteristics will be prioritized:
- •Fasting glucose values between 110-128 mg/dL. Triglycerides = 150-195 mg/dL. HDL-cholesterol: < 50 mg/dL men, < 40 mg/dL women. Blood pressure: systolic > 130 mm Hg; diastolic > 85 mm Hg.
排除标准
- •Subjects taking drugs for hyperglycaemia, hypertension or hypercholesterolaemia.
- •Volunteers participating in other studies or weight loss plans.
- •Pregnant or breastfeeding women.
结局指标
主要结局
Postprandial glucose
时间窗: 0-120 min.
Changes in blood glucose response in treatments B and C will be compared with the baseline results obtained in treatment A. This will be evaluated by area under the curve (AUC) 0-120 min after an Oral Glucose Tolerance Test (OGTT)
次要结局
- Polyphenol metabolites(0-180 min.)
- Urinary uric acid(0-180 min.)
- Postprandial insulin(0-120 min.)
- Postprandial uric acid(0-120 min.)
- Satiety(120 min.)
研究者
Jara Pérez-Jiménez
PhD
National Research Council, Spain