Effects of 28 Days of Different Forms of Creatine Supplementation on Muscle Creatine, Body Composition and Exercise Performance in Recreationally Active Males
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Texas A&M University
- Enrollment
- 48
- Primary Endpoint
- Effects of 28 Days of Different Forms of Creatine Supplementation on Body Water
Study Overview
Brief Summary
This study was designed to examine how different forms of creatine impact active males.
Detailed Description
This study examined the effects of different formulations of creatine nitrate on muscle creatine content, body composition, anaerobic exercise capacity, bench press performance and clinical chemistry panels in recreationally active males.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Health Services Research
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 18 Years to 40 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •participants are apparently healthy and recreationally active males between the ages of 18 and 40;
- •participants will need to have at least six months immediate prior history of resistance training on the bench press and leg press or squat;
Exclusion Criteria
- •participants have a history of treatment for metabolic disease (i.e., diabetes), hypertension, hypotension, thyroid disease, arrhythmias and/or cardiovascular disease;
- •participants are currently using prescription medications;
- •participants have a history of smoking;
- •participants drink excessively (i.e., 12 drinks per week or more);
- •participants have a recent history of creatine supplementation within six weeks of the start of supplementation;
Arms & Interventions
Creatine nitrate
Creatine nitrate (5.0 g. creatine monohydrate + 1.5 g. creatine nitrate that provides 1.0 g. of creatine and 0.5 g. nitrate in 2:1 ratio).
Intervention: Creatine nitrate (Dietary Supplement)
Placebo
6.5 g. dextrose
Intervention: Placebo (Dietary Supplement)
Creatine monohydrate
Creatine monohydrate (6.0 g.) + dextrose (0.5 g.)
Intervention: Creatine monohydrate (Dietary Supplement)
Outcomes
Primary Outcomes
Effects of 28 Days of Different Forms of Creatine Supplementation on Body Water
Time Frame: 28 Days
Assessing Body Water through Bioelectrical Impedance Analysis (BIA)
Effects of 28 Days of Different Forms of Creatine Supplementation on intramuscular creatine
Time Frame: 28 Days
Assessing intramuscular creatine using standard spectrophotometric methods using a microplate spectrophotometer
Effects of 28 Days of Different Forms of Creatine Supplementation on intramuscular ATP
Time Frame: 28 Days
Assessing intramuscular Adenosine Triphosphate (ATP) using standard spectrophotometric methods using a microplate spectrophotometer
Effects of 28 Days of Different Forms of Creatine Supplementation on Body Composition
Time Frame: 28 Days
Assessing Body Compositing through Dual-Energy X-Ray Absorptiometry (DXA)
Effects of 28 Days of Different Forms of Creatine Supplementation on intramuscular phosphocreatine
Time Frame: 28 Days
Assessing intramuscular phosphocreatine using standard spectrophotometric methods using a microplate spectrophotometer
Effects of 28 Days of Different Forms of Creatine Supplementation on anaerobic capacity
Time Frame: 28 Days
Assessing anaerobic capacity through 6 x 6 second sprints followed by a 30 second sprint on a Wingate bicycle ergometer
Effects of 28 Days of Different Forms of Creatine Supplementation on muscular strength
Time Frame: 28 Days
Assessing muscular strength through 1 Repetition Maximum (RM) testing
Effects of 28 Days of Different Forms of Creatine Supplementation on muscular endurance
Time Frame: 28 Days
Assessing muscular endurance through repetition to failure testing
Secondary Outcomes
- Effects of 28 Days of Different Forms of Creatine Supplementation on blood(28 Days)
- Effects of 28 Days of Different Forms of Creatine Supplementation on training volume (weight lifted x number of repetitions x number of sets)(28 Days)
- Effects of 28 Days of Different Forms of Creatine Supplementation on self-reported side effects(28 Days)