Pregnancy and Childbirth in Women with Thalassemia Yesterday and Today: a Multicentre Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- number of pregnancies in women with beta thalassemia followed in Italian centres
研究概览
简要总结
Recent advances in the management of thalassemia have significantly improved life expectancy and quality of life of patients with this hemoglobinopathy, with a consequent increase in their reproductive potential and desire to have children.Since an initial report of a successful pregnancy in a woman with thalassemia major by Walker in 1969, hundreds of pregnancies have been reported so far, highlighting that women carefully managed in the preconception phase usually carry out a successful gestation and labor, both in case of spontaneous conception and assisted reproductive techniques.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Transfusion dependent and nontransfusion- dependent thalassemia
- •Pregnancy ended with the birth of a live or dead foetus
- •Pregnancy ended in miscarriage or voluntary abortion
- •Pregnancy in progress
排除标准
- •Other types of anemia
- •Pregnancy not initiated despite assisted fertilization practices
- •Subjects unwilling to sign informed consent
结局指标
主要结局
number of pregnancies in women with beta thalassemia followed in Italian centres
时间窗: 15 YEARS
To evaluate the number of pregnancies in women with beta thalassemia followed in Italian centres and how the increase in the average age of the thalassemia population impact on the number of new pregnancies over time
number of pregnancies after hormonal stimulation
时间窗: 15 YEARS
number of pregnancies after hormonal stimulation
likelihood of miscarriage
时间窗: 15 YEARS
To evaluate the likelihood of miscarriage
number of pregnancies spontaneously
时间窗: 15 YEARS
many pregnancies occurred spontaneously
foetal death
时间窗: 15 YEARS
To evaluate foetal death
次要结局
未报告次要终点