Autologous Stem Cell Transplantation in Acute Myocardial Infarction
- Conditions
- Acute Anterior Wall Myocardial Infarction
- Registration Number
- NCT00199823
- Lead Sponsor
- Oslo University Hospital
- Brief Summary
Objectives
Intracoronary transplantation of different cell populations have been used in acute myocardial infarction (AMI) with promising results. The primary objective of the ASTAMI study is to test whether intracoronary transplantation of autologous mononuclear bone marrow cells (mBMC) improve left ventricular ejection fraction (LVEF) after anterior wall AMI.
Design
The ASTAMI study is a randomized, controlled, prospective study. One hundred patients with acute anterior wall ST-elevation myocardial infarction (STEMI) treated with acute PCI are randomized in a 1:1 way to either intracoronary transplantation of autologous mBMC 5-8 days after PCI or to control. Left ventricular function, exercise capacity, biochemical status, functional class, quality of life and complications are validated at baseline and during a 12-month follow up.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method whether intracoronary mBMC transplantation improve LVEF after AMI assessed by ECG-gated SPECT.
- Secondary Outcome Measures
Name Time Method To test whether mBMC treatment improve exercise capacity assessed by bicycle ergometry To test whether mBMC treatment improve quality of life assessed by the SF 36 formula
Related Research Topics
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Trial Locations
- Locations (1)
Rikshospitalet-Radiumhospitalet HF
🇳🇴Oslo, Norway