Choice of Anticoagulant for Primary Hemostasis Studies with PFA200® (Platelet Function Analyser)

Recruiting

• Conditions: Hemostasis
• Interventions: Biological: Sampling of 3 additional BAPA tubes

• Registration Number: NCT06753838
• Lead Sponsor: Centre Hospitalier Universitaire Dijon

Brief Summary

The PFA (platelet function analysis) test is prescribed for the exploration of primary hemostasis and the study of platelet-willebrand factor interaction. It is performed using citrated blood, with technical difficulties and frequent alarms that may be linked to the choice of anticoagulant (citrate). It is proposed to compare the results obtained with a conventional citrate tube and a BAPA tube, which is an anticoagulant used in clinical research and which blocks coagulation by another mechanism that would have less impact on blood platelets.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-12-23
• Study First Submitted QC: 2024-12-23
• Study First Posted: 2024-12-31
• Status Verified: 2025-01
• Study Start: 2025-01-21
• Last Update Submitted: 2025-01-21
• Last Update Posted: 2025-01-22
• Primary Completion: 2025-08
• Study Completion: 2025-08

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Person having given their non-opposition
• Person of legal age
• Person receiving a haemostasis consultation at the haemophilia and haemorrhagic diseases treatment center followed by a blood sample with a PFA test prescribed by the doctor (the test is not added for the study).

Exclusion Criteria

• persons under legal protection (curatorship, guardianship)
• persons subject to a court protection order
• pregnant, parturient or breast-feeding women
• adult incapable or unable to give consent
• minor

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients requiring a PFA test for the diagnosis of Willebrand disease	Sampling of 3 additional BAPA tubes	-

Primary Outcome Measures

Name	Time	Method
Occlusion time measurement	at baseline	Measurement of the occlusion times of the 2 cartridges (collagen/ADP and collagen/epinephrine) with the classic 0.109M citrate tube and the BAPA tube, with any PLC alarms and observation of the stained blood smears.

Trial Locations

Locations (1)

CHU Dijon Bourgogne; 🇫🇷 Dijon, France