Carbon Monoxide-Saturated Medium for Islet Isolation
- Conditions
- Chronic Pancreatitis
- Interventions
- Other: Carbon monoxide-bubbled mediums
- Registration Number
- NCT02567240
- Lead Sponsor
- Medical University of South Carolina
- Brief Summary
The goal of this study is to determine whether harvesting islets using carbon monoxide (CO)-saturated mediums can protect islet cell from death after autologous islet transplantation in patients with chronic pancreatitis.
- Detailed Description
Investigators plan to harvest human islets using carbon monoxide-saturated mediums. Survival and function of transplanted islets will be compared with islets harvested using regular mediums.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 16
- Chronic pancreatitis patient selected for total pancreatectomy and islet autotransplantation.
- Age between 18-69.
- Had prior pancreatic surgeries.
Note: The study was initially designed only to enroll diabetes free patients. To increase enrollment, we extended the inclusion criteria by allowing patients who are pre-diabetic to participate the study. This revision was approved by the MUSC IRB on 11/10/2015.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Carbon monoxide-bubbled mediums Carbon monoxide-bubbled mediums Islets will be harvested with Carbon monoxide-saturated mediums
- Primary Outcome Measures
Name Time Method Area under the curve during mixed meal tolerance test 6 months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
GI Surgery, Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States