WO-FCB project: stress and human breastmilk compositio

Completed

Conditions: borstvoeding, stress
stress
10036411

Registration Number: NL-OMON45377

Lead Sponsor: niversiteit van Amsterdam

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 180

Inclusion Criteria

- written informed consent
- maternal age > 18 years
- Mother is planning to fully breastfeed their infant during the first month after giving birth

Exclusion Criteria

- Maternal use of systemic glucocorticoid-medication after giving birth
- Maternal hepatic or renal disorder
- Maternal use of SSRI
- Maternal pre-existing or gestational diabetes
- Major congenital anomalies of the neonate

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Biological measures of maternal stress: cortisol/cortisone levels in maternal<br /><br>saliva<br /><br>- Psychological measures of maternal stress: perceived stress<br /><br>- Breast milk composition (micronutrient content, macronutrient content, fatty<br /><br>acid profile, metabolite content, cortisol/cortisone content)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- (Childhood) stress history of the mother<br /><br>- Perceived maternal stress during pregnancy<br /><br>- Infant temperament assessed at 3 months of age<br /><br>- Anthropometrics of the infant (length, bodyweight, head circumference at 1,<br /><br>2, 3, months of age, which will be collected during the standard visits at the<br /><br>consulatiebureau)<br /><br>- Cortisol content in the infant faecal samples<br /><br>- Food intake of the mother (during the early-lactation phase)</p><br>