Effect of Apical Patency and Local Corticosteroid on Pain and Neuropeptides Release in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Inflammatory markers
研究概览
简要总结
The goal of this randomized clinical trial is to learn the effect of using local corticosteroids and maintaining apical patency in reducing post-preparation pain in patients with acute irreversible pulpitis in molar teeth. The main question it aims to answer is:
• How effective are using local corticosteroids and maintaining apical patency in reducing post-preparation pain in patients with acute irreversible pulpitis? Participants will be asked to fill a visual analogue scale to record their pain, after receiving a root canal treatment while using local corticosteroids or not as well as maintaining apical patency or not.
Researchers will compare the use of corticosteroids and maintaining apical patency in reducing post-operative pain.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 21 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Symptomatic acute irreversible pulpitis in molar teeth.
- •Normal periapical condition including periapical radiography with minimal widening of periodontal ligament.
- •Normal probing depth.
- •No medical condition.
- •No contraindication for administration of corticosteroids and local anesthesia.
排除标准
- •Facial or oral paresthesia.
- •Pregnancy & breastfeeding.
- •Unrestorable tooth.
- •Marginal periodontal disease.
- •Presence of a crown on the tooth involved.
- •Over instrumentation during root canal treatment.
- •Long-term use of corticosteroids.
- •False-positive cases of sensibility test with necrosis discovered after gaining access to the tooth.
- •Cases requiring intrapulpal injection to promote anesthesia.
研究组 & 干预措施
No apical patency
干预措施: Non-corticosteroid injection (Procedure)
No apical patency
干预措施: Corticosteroid injection (Drug)
Apical patency
干预措施: Non-corticosteroid injection (Procedure)
Apical patency
干预措施: Corticosteroid injection (Drug)
结局指标
主要结局
Inflammatory markers
时间窗: before treatment, after 3 days and after 7 days
Gingival crevicular fluid samples were collected by periopaper for testing the level of IL-1β and IL-10
Post-operative pain
时间窗: 6, 12, 24, 48, 72 hour and 7 days postoperative intervals
Patients were instructed to record their pain level using the Visual Analog Scale
次要结局
未报告次要终点
研究者
Mustafa M. Sultan
Teaching assistant
Suez Canal University