Prediction for Systemic Inflammation With Clinical Scoring Systems and Inflammatory Cytokine Levels in Adult Cardiac and Major Abdominal Surgical Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Correlation of clinical scoring systems and inflammatory cytokine levels
研究概览
简要总结
Cardiac surgery with cardiopulmonary bypass (CPB) and hepatic surgery are major operations, associated with a systemic inflammatory response syndrome. The aim of this study is to assess the effectiveness of clinical scoring systems and inflammatory cytokine levels for predicting systemic inflammation. This correlation might identify peri-operative clinical outcomes, then forecast further systemic inflammation in cardiac and hepatic surgical patients.
详细描述
Systemic inflammatory response syndrome (SIRS) is commonly found in most major surgery. Early detection of SIRS will lead to early treatment. Serum cytokines levels are reliable markers for SIRS detection but with high cost and inconvenience. Clinical Scoring Systems are commonly used for assessment of patients with SIRS. If they have good correlation with cytokine levels, they might be used to predict peri-operative clinical outcomes.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult patients who had undergone elective cardiac surgery with CPB
排除标准
- •under 18 years of age
- •needing emergency surgery
- •needing intra-aortic balloon pump
结局指标
主要结局
Correlation of clinical scoring systems and inflammatory cytokine levels
时间窗: 24 h after CPB
Blood samples were collected sequentially at 0, 0.5, 4, 12, and 24 h after CPB for cytokines \[Interleukin (IL)-6, IL-8, and IL-10\] investigation and leukocyte counts. Clinical scoring systems \[Acute Physiology and Chronic Health Evaluation (APACHE) II, Sequential Organ Failure Assessment (SOFA) and Multi-Organ Dysfunction (MOD)\] were calculated and recorded at each time point. Correlations were assessed.
次要结局
未报告次要终点