Cardiovascular and Renal Outcomes of Integrated Management of Blood Pressure and Other Cardiometabolic Risks in Hypertensives：a Multicenter Prospective Cohort Study （UPDATE-cohort）
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30,000
- 试验地点
- 1
- 主要终点
- complex outcome
研究概览
简要总结
this clinical trial is designed to study the cardiovascular and renal outcomes of hypertensives after an integrated management of blood pressure and other cardiometabolic risks. it is a multicenter prospective cohort study.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Outpatients from departments of Cardiology, Endocrinology, Nephrology, Neurology, Geriatrics or General Internal Medicine.
- •Diagnosed as hypertension. Diagnostic criteria: 1)The office BP measured at the day of visit and at least one time before that day were above the cut-off values ( ≥140 mmHg SBP and/or ≥90 mmHg DBP); 2)for patients with normal BP at the day of visit, they should have already been given pre-treatment with antihypertensive drugs ≥ 2 weeks.
- •Voluntary participation.
排除标准
- •Patients aged< 18 years old.
- •Patients without a definite diagnosis of hypertension(for instance, if the patient has been taking antihypertensive drugs irregularly, it is difficult to confirm the diagnosis of hypertension).
- •Patients with a definite diagnosis of secondary hypertension.
- •Patients are diagnosed dyslipidemia with clear cause, such as nephrotic syndrome, severe hypothyroidism, terminal stage of malignancy, etc.
- •Patients are diagnosed end-stage renal disease, hemodialysis, and peritoneal dialysis patients.
- •Patients diagnosed with mental abnormalities who are unable to complete the questionnaire.
- •Patients have once participated in this research during this study cycle(to avoid repeated participation).
结局指标
主要结局
complex outcome
时间窗: follow-up 1 year
number of participants with 3P-MACE events(cardiovascular deaths, non-fatal myocardial infarction, non-fatal stroke)
coronary angioplasty
时间窗: follow-up 1 year
number of participants with coronary angioplasty
acute renal failure
时间窗: follow-up 1 year
number of participants with acute renal failure(eGFR decreases by 50% or \<15ml/min/1.73m2, dialysis or renal death)
acute heart failure
时间窗: follow-up 1 year
number of participants with acute heart failure(non-scheduled hospitalizations due to heart failure or required intravenous medication)
次要结局
未报告次要终点
研究者
Yong Li
Professor, MD, PhD
Huashan Hospital