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临床试验/NCT04531124
NCT04531124尚未招募不适用

Cardiovascular and Renal Outcomes of Integrated Management of Blood Pressure and Other Cardiometabolic Risks in Hypertensives:a Multicenter Prospective Cohort Study (UPDATE-cohort)

Huashan Hospital1 个研究点 分布在 1 个国家目标入组 30,000 人开始时间: 2020年9月1日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
30,000
试验地点
1
主要终点
complex outcome

研究概览

简要总结

this clinical trial is designed to study the cardiovascular and renal outcomes of hypertensives after an integrated management of blood pressure and other cardiometabolic risks. it is a multicenter prospective cohort study.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Outpatients from departments of Cardiology, Endocrinology, Nephrology, Neurology, Geriatrics or General Internal Medicine.
  • Diagnosed as hypertension. Diagnostic criteria: 1)The office BP measured at the day of visit and at least one time before that day were above the cut-off values ( ≥140 mmHg SBP and/or ≥90 mmHg DBP); 2)for patients with normal BP at the day of visit, they should have already been given pre-treatment with antihypertensive drugs ≥ 2 weeks.
  • Voluntary participation.

排除标准

  • Patients aged< 18 years old.
  • Patients without a definite diagnosis of hypertension(for instance, if the patient has been taking antihypertensive drugs irregularly, it is difficult to confirm the diagnosis of hypertension).
  • Patients with a definite diagnosis of secondary hypertension.
  • Patients are diagnosed dyslipidemia with clear cause, such as nephrotic syndrome, severe hypothyroidism, terminal stage of malignancy, etc.
  • Patients are diagnosed end-stage renal disease, hemodialysis, and peritoneal dialysis patients.
  • Patients diagnosed with mental abnormalities who are unable to complete the questionnaire.
  • Patients have once participated in this research during this study cycle(to avoid repeated participation).

结局指标

主要结局

complex outcome

时间窗: follow-up 1 year

number of participants with 3P-MACE events(cardiovascular deaths, non-fatal myocardial infarction, non-fatal stroke)

coronary angioplasty

时间窗: follow-up 1 year

number of participants with coronary angioplasty

acute renal failure

时间窗: follow-up 1 year

number of participants with acute renal failure(eGFR decreases by 50% or \<15ml/min/1.73m2, dialysis or renal death)

acute heart failure

时间窗: follow-up 1 year

number of participants with acute heart failure(non-scheduled hospitalizations due to heart failure or required intravenous medication)

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Yong Li

Professor, MD, PhD

Huashan Hospital

研究点 (1)

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