The Effects of Miminal Stimulation Protocol on Preimplantation Genetic Screening

• Conditions: Preimplantation Genetic Screening
• Interventions: Genetic: protocol

• Registration Number: NCT05220995
• Lead Sponsor: Gokalp Oner

Brief Summary

PGS has been the most effective method for embryo selection in IVF cycles. Euploidy rates decrease significantly with advancing maternal age (AMA). The dosage of gonadotropins also may be increased to recruit an adequate number of follicles in AMA women, minimal Stimulation Protocol (MSP) with the new combination of human menopausal gonadotrophin (hMG) and clomiphene citrate (CC) for controlled ovarian hyperstimulation is defined for poor ovarian response women. The aim of this study is to show minimal stimulation protocol affect euploidy and pregnancy rates in preimplatation genetic screening (PGS) cycles with single embryo transfer.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-05-15
• Status Verified: 2022-01
• Primary Completion: 2022-01-23
• Study Completion: 2022-01-25
• Study First Submitted: 2022-01-31
• Study First Submitted QC: 2022-01-31
• Last Update Submitted: 2022-01-31
• Study First Posted: 2022-02-02
• Last Update Posted: 2022-02-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 200

Inclusion Criteria

Advanced maternal aged -

Exclusion Criteria

Severe male factor, endometriosis, and absolute tubal factor were excluded in this study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
100 patients with minimal	protocol	In advancing maternal age (AMA) women, minimal stimulation protocol (MSP) with the new combination of human menopausal gonadotrophin (hMG) and clomiphene citrate (CC) were performed for controlled ovarian hyperstimulation is defined for poor ovarian response women.
100 patients with recombinant FSH antagonist protocol	protocol	In advancing maternal age (AMA) women, flexible antagonist protocol with recombinant FSH were performed for controlled ovarian hyperstimulation is defined for poor ovarian response women.

Primary Outcome Measures

Name	Time	Method
euploid rates	3 months	the effects of different stimulation protocols on euploid rates

Secondary Outcome Measures

Name	Time	Method
pregnancy rates	3 months	the effects of different stimulation protocols on pregnancy rates

Trial Locations

Locations (1)

Gokalp Oner; 🇹🇷 Kayseri, Gevher Nesibe, Turkey