Differential Adaptation of Renal Function in Two Types of Intense Physical Exercise
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Absolute change in urinary Kidney Injury Molecule-1 (KIM-1) levels
研究概览
简要总结
In recent years there has been a significant increase in the number of participants in high intensity and duration sports events. This type of physical exercise has been reported to lead to an apparently transitory deterioration in kidney function. The injury mechanisms involved in this process have not been fully studied, but several have been proposed as potential causes, such as tissue ischemia, disruption of the permeability of the glomerular basement membrane, damage to the ultra-structure of skeletal muscle, structural involvement of the renal parenchyma, exercise-associated hyperthermia or insufficient hydration during exercise.
Urinary biomarkers, which are a more precise tool than serum creatinine when it comes to detecting subclinical kidney damage, may be key to elucidate the characteristics of exercise-related kidney injury.
The aim of this study is to carry out an integrative analysis of the development of exercise-associated subclinical acute kidney injury.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥18 years.
- •Able to understand the objectives of the study and to provide informed consent.
- •Body mass index between 18.5 and 24.9 kg / m2
- •Active sportsman/woman (defined as previous experience with the planned tests and performing vigorous-intensity aerobic activity at least three times per week).
排除标准
- •History of chronic kidney disease, hypertension, uncontrolled diabetes (defined as fasting glucose levels ≥200 mg/dl or HbA1c ≥9%), peripheral vascular disease, heart disease, neurological disease or thyroid disease.
- •Use of NSAIDs in the 72h prior to the test.
- •Consumption of statins or anabolic steroids.
- •Some kind of major physical injury in the four months prior to the tests.
研究组 & 干预措施
10 km continuous running
Participants will perform a test of 10 km coninuous running.
干预措施: 10 km continuous running (Other)
10 km continuous running
Participants will perform a test of 10 km coninuous running.
干预措施: 1.5 km continuous swimming (Other)
1.5 km swimming
Participants will perform a test of 1.5 km coninuous swimming.
干预措施: 10 km continuous running (Other)
1.5 km swimming
Participants will perform a test of 1.5 km coninuous swimming.
干预措施: 1.5 km continuous swimming (Other)
结局指标
主要结局
Absolute change in urinary Kidney Injury Molecule-1 (KIM-1) levels
时间窗: 24 hours
Absolute change in urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) levels
时间窗: 24 hours
次要结局
- Absolute change in proteinuria(24 hours)
- Absolute change in serum creatinine levels(24 hours)
研究者
Armando Coca Rojo
MD, MSc, phD
Hospital Clínico Universitario de Valladolid