Study of Metabolic Connectivity in Drug-resistant Temporal Epilepsy

Completed

• Conditions: Epilepsy

• Registration Number: NCT05455047
• Lead Sponsor: Central Hospital, Nancy, France

Brief Summary

18F-Fluoro-deoxy-glucose (18F-FDG) positron emission tomography (PET) has a high sensitivity for temporal lobe epilepsy (TLE), the most common form of focal epilepsy, with a detection range of 86-90% . Therefore, 18F-FDG PET is a useful tool to identify the epileptogenic zone (ETZ) in the inter-ictal phase of drug-resistant temporal epilepsy during pre-surgical evaluation . Based on stereotactic electroencephalography (SEEG) findings, a correspondence between electrical data and metabolic changes on PET was found at the group level by identifying four different patterns of TLE . As expected, hypometabolism was not limited to the EZ defined by SEEG, but underlay broader epileptic networks . Because of the different electroclinical presentations of TLE, 18F-FDG PET appears to be a very useful tool in these temporal epilepsies. Indeed, it has been recently demonstrated that a gradient of PET hypometabolism from the uninvolved area to the spreading area, then to the epileptogenic area and to the lesion area is observed with consequently a good performance of 18F-FDG PET in defining the EZ .

Therefore, it is interesting to study PET metabolism as a network and not as a combination of regional metabolic measures in epilepsy.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-10-13
• Status Verified: 2021-12
• Study Start: 2022-02-01
• Primary Completion: 2022-03-01
• Study Completion: 2022-06-01
• Study First Submitted QC: 2022-07-11
• Study First Posted: 2022-07-13
• Last Update Submitted: 2022-08-23
• Last Update Posted: 2022-08-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Patients with drug-resistant temporal epilepsy with an accurate diagnosis on SEEG
• Patients with epilepsy who have had a PET/CT scan with 18F-FDG as part of a pre-operative assessment
• Person having received complete information on the organization of the research and not having objected to the use of these data;
• Patients affiliated to a social security system

Exclusion Criteria

• Person who has not received full information on the organization of the research and who has opposed the use of this data
• A person of full age who is the subject of a legal protection measure (guardianship, curatorship, safeguard of justice).
• A person of full age who is unable to give consent and who is not subject to a legal protection measure

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Metabolic connectivity	1 month	Metabolic connectivity of hypometabolic clusters in each temporal epilepsy subgroup defined by IRCA (interregional correlation analysis) and graph theory

Trial Locations

Locations (1)

Nancy's Hospital; 🇫🇷 Vandœuvre-lès-Nancy, France