The pathophysiology of post-extubation dysphagia in ICU patients

Completed

• Conditions: slikstoornissen; Dysphagia; swallowing disorders; 10007867; 10022114

• Registration Number: NL-OMON48639
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

• Age >= 18 years
• Informed consent
• Extubated after endotracheal intubation for more than 5 days (> 5 days)
• Between RASS -2 and +2
• Able to sit right up
• No respiratory insufficiency/failure (for this study defined as a SpO2 < 92%
with a minimum of 3 L nasal oxygen).

Inclusion criteria of the group of healthy persons:
• Age >= 18 years
• Informed consent

Exclusion Criteria

• Pre-existing dysphagia
• Tracheostomy or previous tracheostomy
• History of prior intubation < 3 months ago
• Head/neck surgery, head/neck radiation or head/neck disease
• Pre-existent esophageal disorder
• Coagulopathy (thrombocytes < 50*10^9 /l, or PT/APTT > 1.5 times the reference
value, or fibrinogen < 1000 mg/l, or use of therapeutic anticoagulation drugs)
• Allergy for xylometazoline (only if indicated)
• Allergy for methylene blue
• Known pregnancy
• Known G6PD deficiency

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the underlying pathophysiology of PED, which will<br /><br>be described qualitatively. Goal is to classify patients into<br /><br>pathophysiological categories.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary outcome parameters are the feasibility of the combination of<br /><br>techniques and possible interactions.</p><br>